Mechanistic insights into the reduced developmental capacity of in vitro matured oocytes and importance of cumulus cells in oocyte quality determination
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29786
Abstract: In vitro maturation of oocytes is a promising assisted reproductive technology (ART) for infertility treatment, although it is still not a routine technique for human ART due to reduced embryonic development. The aim of the… read more here.
Keywords: vitro matured; reduced developmental; matured oocytes; capacity vitro ... See more keywords
TBX2 affects proliferation, apoptosis and cholesterol generation by regulating mitochondrial function and autophagy in bovine cumulus cell
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.1009
Abstract: Abstract Background T‐box transcription factor 2 (TBX2) is a member of T‐box gene family whose members are highly conserved in evolution and encoding genes and are involved in the regulation of developmental processes. The encoding… read more here.
Keywords: cell; function; cholesterol; cumulus cells ... See more keywords
High copper concentrations produce genotoxicity and cytotoxicity in bovine cumulus cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-017-9683-0
Abstract: The aim of this study was to investigate the cytotoxic and genotoxic effects of high copper (Cu) concentrations on bovine cumulus cells (CCs) cultured in vitro. We evaluated the effect of 0, 120, 240, and… read more here.
Keywords: high copper; 120 240; copper concentrations; bovine cumulus ... See more keywords
Beauvericin alters the expression of genes coding for key proteins of the mitochondrial chain in ovine cumulus-oocyte complexes.
Sign Up to like & getrecommendations! Published in 2020 at "Mycotoxin research"
DOI: 10.1007/s12550-020-00409-5
Abstract: Beauvericin (BEA) is a member of the enniatin family of mycotoxins which has received increasing interest because of frequent occurrence in food and feed. By its ionophoric properties, BEA is able to alter membrane ion… read more here.
Keywords: cumulus cells; expression genes; proteins mitochondrial; genes coding ... See more keywords
Abundances of autophagy-related protein LC3B in granulosa cells, cumulus cells, and oocytes during atresia of pig antral follicles.
Sign Up to like & getrecommendations! Published in 2019 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2019.106225
Abstract: In mammals, apoptosis has been accepted as the type of programmed cell death (PCD) that occurs in ovarian follicles undergoing atresia. Results of recent studies, however, indicate autophagy may be an alternative mechanism involved in… read more here.
Keywords: protein; granulosa cells; atretic follicles; autophagy related ... See more keywords
Impaired mitochondrial stress response in cumulus cells is associated with increased apoptosis and accelerated follicular depletion
Sign Up to like & getrecommendations! Published in 2018 at "Fertility and Sterility"
DOI: 10.1016/j.fertnstert.2018.07.300
Abstract: OBJECTIVE: Caseinolytic peptidase P (CLPP) mediates degradation of mitochondrial misfolded proteins to maintain homeostasis under metabolic stress. CLPP is a key factor for mitochondrial function and targeted global germline deletion of Clpp results in female… read more here.
Keywords: cumulus cells; accelerated follicular; follicular depletion; stress ... See more keywords
10-Gingerol as an inducer of apoptosis through HTR1A in cumulus cells: In-vitro and in-silico studies
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Taibah University Medical Sciences"
DOI: 10.1016/j.jtumed.2017.05.012
Abstract: Objectives Cumulus cells play a crucial role as essential mediators in the maturation of ova. Ginger contains 10-gingerol, which induces apoptosis in colon cancer cells. Based on this hypothesis, this study aimed to determine whether… read more here.
Keywords: cumulus cells; inducer apoptosis; gingerol inducer; apoptosis ... See more keywords
Human bone morphogenetic protein 8A promotes expansion and prevents apoptosis of cumulus cells in vitro
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111121
Abstract: Cumulus expansion is essential for ovulation and oocyte maturation in mammals. Previous studies suggest that this process requires certain cumulus expansion enabling factors, induced by LH surge, that activate SMAD signaling locally. However, their identities… read more here.
Keywords: protein; expansion; human bone; cumulus cells ... See more keywords
Altered transcriptome in cumulus cells of infertile women with advanced endometriosis with and without endometrioma.
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2021.01.024
Abstract: RESEARCH QUESTION Is the transcriptome of cumulus cells of infertile women with advanced endometriosis (EIII/IV), with and without endometrioma, altered? DESIGN In this prospective case-control study, next-generation RNA sequencing was used to compare the transcript… read more here.
Keywords: endometrioma; cells infertile; without endometrioma; infertile women ... See more keywords
Susceptibility of human cumulus cells to bisphenol a In vitro.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2017.09.008
Abstract: Bisphenol A (BPA) is detectable in follicular fluid. However, the effect of BPA exposure on human cumulus cells (CC) that surround the oocyte and are crucial for oocyte competence has been largely unexplored. We exposed… read more here.
Keywords: susceptibility human; bpa; human cumulus; cumulus cells ... See more keywords
TMT-based quantitative proteomic analysis of cumulus cells derived from vitrified porcine immature oocytes following in vitro maturation.
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.04.025
Abstract: As the immature oocytes are submitted to cryopreservation, their surrounding cumulus cells (CCs) will inevitably suffer, which may have some adverse effects on subsequent oocyte maturation and development. So far, little is known about the… read more here.
Keywords: derived vitrified; vitrified porcine; immature oocytes; cumulus cells ... See more keywords