The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA
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DOI: 10.1002/glia.23170
Abstract: BNN27, a member of a chemical library of C17‐spiroepoxy derivatives of the neurosteroid DHEA, has been shown to regulate neuronal survival through its selective interaction with NGF receptors (TrkA and p75NTR), but its role on… read more here.
Keywords: cuprizone; novel synthetic; mature oligodendrocytes; ngf ... See more keywords
Cuprizone‐induced graded oligodendrocyte vulnerability is regulated by the transcription factor DNA damage‐inducible transcript 3
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23538
Abstract: Oligodendrocytes are integral to efficient neuronal signaling. Loss of myelinating oligodendrocytes is a central feature of many neurological diseases, including multiple sclerosis (MS). The results of neuropathological studies suggest that oligodendrocytes react with differing sensitivity… read more here.
Keywords: transcription; cuprizone; oligodendrocyte vulnerability; vulnerability ... See more keywords
Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice
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DOI: 10.1002/glia.24583
Abstract: The kappa opioid receptor has been identified as a promising therapeutic target for promoting remyelination. In the current study, we evaluated the ability of nalfurafine to promote oligodendrocyte progenitor cell (OPC) differentiation and myelination in… read more here.
Keywords: treatment; myelination; demyelination; cuprizone rapamycin ... See more keywords
Continuous cuprizone intoxication allows active experimental autoimmune encephalomyelitis induction in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2019 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-019-01786-4
Abstract: Oligodendrocyte degeneration is a hallmark of multiple sclerosis pathology, and protecting oligodendrocytes and myelin is likely to be of clinical relevance. Traditionally, oligodendrocyte and myelin degeneration are viewed as a direct consequence of an inflammatory… read more here.
Keywords: cuprizone; intoxication; autoimmune encephalomyelitis; active experimental ... See more keywords
Microglia polarization by methylprednizolone acetate accelerates cuprizone induced demyelination
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DOI: 10.1007/s10735-018-9786-z
Abstract: Glucocorticoids (GC) are known as inflammatory drugs, which are used in neuroinflammatory diseases. Unlike the classic picture, recent studies have revealed that some GC drugs exacerbate inflammatory responses in their acute and prolonged administration. Multiple… read more here.
Keywords: induced demyelination; demyelination; cuprizone; cpz ... See more keywords
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-019-09824-0
Abstract: Oxidative stress with mitochondrial defects has a central role in the development and deterioration of Multiple sclerosis (MS). According to new findings of the effects of metformin on mitochondrial function, has attracted a lot of… read more here.
Keywords: cuprizone; metformin; cuprizone induced; multiple sclerosis ... See more keywords
Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2.
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DOI: 10.1007/s10753-021-01447-6
Abstract: Multiple sclerosis is a chronic inflammatory neurodegenerative disease of the central nervous system which injures the myelin sheath. Telmisartan and nifedipine are antihypertensive drugs that recently showed neuroprotective properties against neurodegenerative diseases. This study evaluated… read more here.
Keywords: induced demyelination; cuprizone; telmisartan nifedipine; cuprizone induced ... See more keywords
Nrf2 deficiency increases oligodendrocyte loss, demyelination, neuroinflammation and axonal damage in an MS animal model
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-019-00488-z
Abstract: Oxidative stress is a pathophysiological hallmark of many CNS diseases, among multiple sclerosis (MS). Accordingly, boosting the astrocytic transcription factor nuclear factor E2-related factor 2 (Nrf2) system in an MS mouse model efficiently ameliorates oligodendrocyte… read more here.
Keywords: axonal damage; cuprizone; neuroinflammation; model ... See more keywords
Yokukansan Reduces Cuprizone-Induced Demyelination in the Corpus Callosum Through Anti-inflammatory Effects on Microglia
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DOI: 10.1007/s11064-017-2400-z
Abstract: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). The release of inflammatory cytokines and pro-oxidant molecules from microglia has been shown to play a key role in the pathology… read more here.
Keywords: anti inflammatory; demyelination; cuprizone; yokukansan reduces ... See more keywords
Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination
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DOI: 10.1007/s12031-017-0924-y
Abstract: Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that is characterized by myelin abnormalities, oligodendrocyte pathology, and concomitant glia activation. Unclear are the factors triggering gliosis and demyelination. New findings… read more here.
Keywords: induced demyelination; demyelination; cuprizone; glial cell ... See more keywords
Comparative Neuroprotective Potential of Nanoformulated and Free Resveratrol Against Cuprizone-Induced Demyelination in Rats
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DOI: 10.1007/s12035-024-04415-x
Abstract: Demyelination is a frequent yet crippling neurological disease associated with multiple sclerosis (MS). The cuprizone (CZ) model, which causes demyelination through oxidative stress and neuroinflammation, is a popular tool used by researchers to examine this… read more here.
Keywords: ionp resv; resveratrol; demyelination; comparative neuroprotective ... See more keywords