Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone‐induced demyelination
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23229
Abstract: The regeneration of oligodendrocytes is a crucial step in recovery from demyelination, as surviving oligodendrocytes exhibit limited structural plasticity and rarely form additional myelin sheaths. New oligodendrocytes arise through the differentiation of platelet‐derived growth factor… read more here.
Keywords: induced demyelination; demyelination; matter; gray matter ... See more keywords
Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-019-09824-0
Abstract: Oxidative stress with mitochondrial defects has a central role in the development and deterioration of Multiple sclerosis (MS). According to new findings of the effects of metformin on mitochondrial function, has attracted a lot of… read more here.
Keywords: cuprizone; metformin; cuprizone induced; multiple sclerosis ... See more keywords
Neuroprotective Effects of Telmisartan and Nifedipine Against Cuprizone-Induced Demyelination and Behavioral Dysfunction in Mice: Roles of NF-κB and Nrf2.
Sign Up to like & getrecommendations! Published in 2021 at "Inflammation"
DOI: 10.1007/s10753-021-01447-6
Abstract: Multiple sclerosis is a chronic inflammatory neurodegenerative disease of the central nervous system which injures the myelin sheath. Telmisartan and nifedipine are antihypertensive drugs that recently showed neuroprotective properties against neurodegenerative diseases. This study evaluated… read more here.
Keywords: induced demyelination; cuprizone; telmisartan nifedipine; cuprizone induced ... See more keywords
Formyl Peptide Receptor 1-Mediated Glial Cell Activation in a Mouse Model of Cuprizone-Induced Demyelination
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-017-0924-y
Abstract: Multiple sclerosis (MS) is a chronic degenerative disease of the central nervous system that is characterized by myelin abnormalities, oligodendrocyte pathology, and concomitant glia activation. Unclear are the factors triggering gliosis and demyelination. New findings… read more here.
Keywords: induced demyelination; demyelination; cuprizone; glial cell ... See more keywords
Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR‐136‐5p and long non‐coding RNA HOTAIR in cuprizone‐induced demyelination
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.06.028
Abstract: Graphical abstract Figure. No caption available. &NA; Sulfasalazine (SF) promotes remyelination and improves the outcome of multiple sclerosis (MS) patients. However, the underlining mechanism remains elusive. Here, we examined whether SF blocks microglia switching to… read more here.
Keywords: induced demyelination; cuprizone; hotair; cuprizone induced ... See more keywords
Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models
Sign Up to like & getrecommendations! Published in 2021 at "Brain Sciences"
DOI: 10.3390/brainsci11020272
Abstract: Suitable in vivo and in vitro models are instrumental for the development of new drugs aimed at improving symptoms or progression of multiple sclerosis (MS). The cuprizone (CPZ)-induced murine model has gained momentum in recent… read more here.
Keywords: demyelination; cell lines; induced neurotoxicity; cuprizone induced ... See more keywords
Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12121687
Abstract: Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant demyelination, behavioural… read more here.
Keywords: cuprizone; demyelination; model; cuprizone induced ... See more keywords
In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination
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DOI: 10.3390/diagnostics11010045
Abstract: This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy. Nineteen Sprague Dawley rats were… read more here.
Keywords: induced demyelination; cuprizone; cuprizone induced; rat model ... See more keywords
Ferroptosis: copper-iron connection in cuprizone-induced demyelination
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.314300
Abstract: Redox active metals such as iron, copper, zinc, and manganese play important roles in promoting a variety of biochemical reactions essential for cellular function. This is made possible by the ability of these metals to… read more here.
Keywords: demyelination; copper; ferroptosis; cuprizone induced ... See more keywords