The protective effect of curcumin on cardiac markers and fibrosis in abemaciclib‐induced cardiac damage in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23226
Abstract: Abemaciclib (ABE) is a cyclin‐dependent kinase inhibitor used in combination with an antiestrogen in the treatment of breast cancer. In addition to the important therapeutic properties of this drug, its side effects are not fully… read more here.
Keywords: cardiac damage; damage; cur; effect curcumin ... See more keywords
Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7658
Abstract: Chronic traumatic stress results in various psychiatric disorders, especially posttraumatic stress disorder (PTSD). Previous study demonstrated that curculigoside (CUR) a component of Rhizoma Curculiginis prevented fear extinction and stress‐induced depression‐like behaviors. However, its effects on… read more here.
Keywords: pka signaling; signaling pathway; cur; pka ... See more keywords
Transdermal delivery of curcumin-loaded supramolecular hydrogels for dermatitis treatment
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Materials Science: Materials in Medicine"
DOI: 10.1007/s10856-018-6215-5
Abstract: AbstractCurcumin (CUR) is a hydrophobic polyphenol with anti-inflammatory activity. However, its low water-solubility and poor skin permeation limited its application in the treatment of dermititis. CUR-loaded micelles were prepared using thin membrane hydration method with… read more here.
Keywords: supramolecular hydrogels; treatment; loaded supramolecular; cur ... See more keywords
Curcumin Loaded Fe3O4 Nanoparticles: An MRI Contrast Agent to Investigate the Impact of Curcumin on Maximizing Negative Contrast and r2 Relaxation Rate
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Inorganic and Organometallic Polymers and Materials"
DOI: 10.1007/s10904-018-0868-x
Abstract: The goal of this project was to fabricate a diagnostic system based on polyethylenimine (PEI) coated superparamagnetic iron oxide nanoparticles (Fe3O4 NPs) containing curcumin (CUR) in order to appraise the influence of CUR on increase… read more here.
Keywords: fe3o4 pei; contrast; pei cur; cur ... See more keywords
Enzymatic formation of curcumin in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Nano Research"
DOI: 10.1007/s12274-018-1994-z
Abstract: The recent classification of curcumin (Cur) as a pan-assay interference compound (PAINS) and an invalid metabolic panaceas (IMPS) candidate demonstrated the controversial nature of Cur as a drug lead owing to its aggregation in aqueous… read more here.
Keywords: formation curcumin; vitro vivo; curcumin vitro; enzymatic formation ... See more keywords
Novel dual ROS-sensitive and CD44 receptor targeting nanomicelles based on oligomeric hyaluronic acid for the efficient therapy of atherosclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115787
Abstract: Although the clinical usage of drugs administration was raising, the application of nanoparticles encapsulating the hydrophobic drugs with plummy efficiency was very scarce for atherosclerosis (AS) treatment. In this work, a novel dual ROS-sensitive and… read more here.
Keywords: hasf cur; dual ros; cur micelles; cur ... See more keywords
Core-shell pea protein-carboxymethylated corn fiber gum composite nanoparticles as delivery vehicles for curcumin.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2020.116273
Abstract: Nanocomposites from plant-derived polysaccharides and proteins are green and sustainable materials that can be applied in various food and biomedical fields. In this work, we developed a novel core-shell nanocomposite from carboxymethylated corn fiber gum… read more here.
Keywords: carboxymethylated corn; core shell; delivery; cur ... See more keywords
Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2019.108865
Abstract: Treatment of breast cancer by paclitaxel (PAX) often encounters therapeutic failure most likely caused by innate/acquired resistance. Cancer stem cells (CSCs) and multidrug resistance complex (MDR-1 or P-glycoprotein) overexpression are main mechanisms implicated in chemoresistance.… read more here.
Keywords: resistance; pax; cur; breast cancer ... See more keywords
Development of PCL/PEO electrospun fibrous membranes blended with silane-modified halloysite nanotube as a curcumin release system
Sign Up to like & getrecommendations! Published in 2020 at "Applied Clay Science"
DOI: 10.1016/j.clay.2019.105430
Abstract: Abstract In this work, electrospun fibrous membranes based on the polycaprolactone (PCL)/polyethylene oxide (PEO) blended with pure, 3-Aminopropyltriethoxysilane (APTES) or 3-Glycidoxypropyltrimethoxysilane (GPTMS) modified halloysite nanotubes (HNT) were prepared by electrospinning for curcumin (Cur) delivery system.… read more here.
Keywords: peo; microscopy; fibrous membranes; pcl peo ... See more keywords
Surfactant‐free solid dispersion of BCS class IV drug in an amorphous chitosan oligosaccharide matrix for concomitant dissolution in vitro ‐ permeability increase
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.01.031
Abstract: ABSTRACT Saccharides have been applied as a water‐soluble matrix for dispersing hydrophobic drugs homogeneously without the need to use surfactants in amorphous solid dispersions (ASD). Up to now, concomitant permeability improvement of BCS Class IV… read more here.
Keywords: class drug; drug; permeability; bcs class ... See more keywords
An enzyme-mediated controlled release system for curcumin based on cyclodextrin/cyclodextrin degrading enzyme.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2020.109727
Abstract: In this study, an enzyme-triggered system based on β-cyclodextrin (β-CD) has been developed to achieve controlled release of hydrophobic drugs in the presence of maltogenic amylase (MAase). The inclusion complex formation of curcumin (CUR), as… read more here.
Keywords: system; controlled release; cyclodextrin; cur ... See more keywords