Preparation of Curcuma comosa tablets using liquisolid techniques: In vitro and in vivo evaluation
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DOI: 10.1016/j.ijpharm.2018.10.031
Abstract: &NA; Curcuma comosa (C. comosa) is a Thai medicinal herb that provides numerous pharmacologic activities due to its estrogen‐like action. This study aimed to investigate the use of liquisolid technique to prepare tablets containing oleoresin‐like… read more here.
Keywords: comosa; comosa tablets; curcuma comosa; dissolution ... See more keywords
Lowering of lysophosphatidylcholines in ovariectomized rats by Curcuma comosa
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DOI: 10.1371/journal.pone.0268179
Abstract: Decline of ovarian function in menopausal women increases metabolic disease risk. Curcuma comosa extract and its major compound, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (DPHD), improved estrogen-deficient ovariectomized (OVX) rat metabolic disturbances. However, information on their effects on metabolites is… read more here.
Keywords: extract; rat; lowering lysophosphatidylcholines; curcuma comosa ... See more keywords
Effect of Curcuma comosa extracts on the functions of peptide transporter and P-glycoprotein in intestinal epithelial cells.
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DOI: 10.1691/ph.2017.6147
Abstract: Curcuma comosa has been widely used as a herbal medicine in Thailand; however, it remains unclear whether C. comosa influences the absorption of drugs that are substrates for the transporters in the small intestine. In… read more here.
Keywords: peptide transporter; medicine; comosa; comosa extracts ... See more keywords
Formulation and In Vitro Evaluation of Mucoadhesive Sustained Release Gels of Phytoestrogen Diarylheptanoids from Curcuma comosa for Vaginal Delivery
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DOI: 10.3390/pharmaceutics15010264
Abstract: Diarylheptanoids (DAs) characterized by a 1,7-diphenylheptane structural skeleton are considered a novel class of phytoestrogens. The DAs available in Curcuma comosa Roxb. (C. comosa) extract demonstrated significant estrogenic activities both in vitro and in vivo.… read more here.
Keywords: comosa gels; curcuma comosa; release; sustained release ... See more keywords