Inhibition of autophagic flux by the curcumin analog EF‐24 and its antiproliferative effect on MCF‐7 cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23307
Abstract: 5‐Bis[(2‐fluorophenyl)methylene]‐4‐piperidinone (EF‐24) is a curcumin analog, which was identified for its physiochemical stability and diverse pharmacological functions. In the present study, EF‐24 was added to the breast cancer cell line MCF‐7 and its cellular effects… read more here.
Keywords: mcf; autophagic flux; curcumin analog; mcf cells ... See more keywords
AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101413
Abstract: Drug resistance is the main obstacle in the improvement of chemotherapeutic efficacy in glioblastoma. Previously, we showed that dehydroepiandrosterone (DHEA), one kind of androgen/neurosteroid, potentiates glioblastoma to acquire resistance through attenuating DNA damage. Androgen receptor… read more here.
Keywords: glioblastoma; resistant glioblastoma; curcumin analog; resistance ... See more keywords
Design, synthesis and evaluation of novel curcumin analog as potential anti-lung cancer agent
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2022.2095264
Abstract: Abstract Curcumin is a polyphenolic compound derived from the plant turmeric and the structural instability of which limits its further clinical applications. In this study, 11 curcumin analogs with more stable scaffold were prepared and… read more here.
Keywords: lung cancer; curcumin analog; curcumin;
Curcumin analog HO‐3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17248
Abstract: Human oral squamous cell carcinoma (OSCC) is the common head and neck malignancy in the world. While surgery, radiotherapy and chemotherapy are emerging as the standard treatment for OSCC patients, the outcome is limited to… read more here.
Keywords: cell carcinoma; cell; squamous cell; curcumin analog ... See more keywords
Inhibition of JNK Phosphorylation by Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury [Corrigendum]
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s357280
Abstract: [This corrects the article DOI: 10.2147/DDDT.S215712.]. read more here.
Keywords: jnk phosphorylation; inhibition jnk; curcumin analog; c66 protects ... See more keywords
FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s131051
Abstract: Background Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that primarily affects premature infants. It is characterized by inflammation and leukocyte infiltration that can progress to intestinal necrosis, perforation, systemic inflammatory response, and death. In… read more here.
Keywords: curcumin analog; flll32 curcumin; intestinal injury; necrotizing enterocolitis ... See more keywords
In Vitro Efficacy and Molecular Mechanism of Curcumin Analog in Pathological Regulation of Spinocerebellar Ataxia Type 3
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11071389
Abstract: Unlike other nuclear factor erythroid-2-related factor 2 (Nrf2) activators, the mechanism of action of curcumin analog, ASC-JM17 (JM17), in regulating oxidative homeostasis remains unknown. Spinocerebellar ataxia type 3 (SCA3) is an inherited polyglutamine neurodegenerative disease… read more here.
Keywords: ataxia type; jm17; curcumin analog; spinocerebellar ataxia ... See more keywords