Curcumin Upregulates miR-148a to Increase the Chemosensitivity of CD44-Positive Prostate Cancer Stem Cells to Paclitaxel Through Targeting the MSK1/IRS1 axis.
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DOI: 10.1055/a-1867-4805
Abstract: BACKGROUND In men, prostate cancer (PC) is the second most common cause of cancer-related death. However, paclitaxel resistance is a major challenge in advanced PC. Curcumin, a natural antioxidant, has been demonstrated to have cytotoxic… read more here.
Keywords: prostate cancer; cancer stem; mir 148a; curcumin paclitaxel ... See more keywords
Construction of Curcumin and Paclitaxel Co-Loaded Lipid Nano Platform and Evaluation of Its Anti-Hepatoma Activity in vitro and Pharmacokinetics in vivo
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DOI: 10.2147/ijn.s399289
Abstract: Purpose The present study aimed to construct a co-loading platform encapsulating curcumin and paclitaxel at ratios of 2:1–80:1 (w/w) designated “CU-PTX-LNP” and explored the synergistic effects of CU-PTX at different composite proportions on liver cancer… read more here.
Keywords: curcumin paclitaxel; platform; ptx lnp; ptx ... See more keywords
Curcumin enhances the anti-cancer efficacy of paclitaxel in ovarian cancer by regulating the miR-9-5p/BRCA1 axis
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DOI: 10.3389/fphar.2022.1014933
Abstract: Background: Patients with late-stage ovarian cancer still have a very poor prognosis due to chemotherapy resistance. Curcumin has been shown to synergistically enhance the therapeutic effects of multiple chemotherapeutic agents, but the potential involvement of… read more here.
Keywords: ovarian cancer; anti cancer; mir brca1; curcumin paclitaxel ... See more keywords
Modulatory Effects of Biosynthesized Gold Nanoparticles Conjugated with Curcumin and Paclitaxel on Tumorigenesis and Metastatic Pathways—In Vitro and In Vivo Studies
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DOI: 10.3390/ijms23042150
Abstract: Background: Breast cancer is the most common cancer in women globally, and diagnosing it early and finding potential drug candidates against multi-drug resistant metastatic breast cancers provide the possibilities of better treatment and extending life.… read more here.
Keywords: cancer; vitro vivo; gold nanoparticles; gold ... See more keywords
The role of cur ole of curcumin against paclitax cumin against paclitaxel-induced o el-induced oxidativ xidative stress and DNA damage in testes of adult male rats.
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DOI: 10.55730/1300-0144.5556
Abstract: BACKGROUND Paclitaxel is a widely used drug for the treatment of cancer, but it possesses toxic effects on male reproductive system. Administering paclitaxel with an antioxidant has become a strategy for preventing the side effects… read more here.
Keywords: paclitaxel group; damage; curcumin; curcumin paclitaxel ... See more keywords