(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29580
Abstract: We have extended our analyses of (curcumin+sildenafil) biology. The drug combination caused vascularization and degradation of mutant K‐RAS that correlated with reduced phosphorylation of ERK1/2, AKT T308, mTORC1, mTORC2, ULK1 S757, STAT3, STAT5, and NFκB… read more here.
Keywords: ulk1 s317; drug; atm ampk; curcumin sildenafil ... See more keywords
Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19807
Abstract: The present studies focused on the ability of the phosphodiesterase 5 (PDE5) inhibitor sildenafil to enhance the anti-cancer properties of clinically relevant concentrations of the dietary diarylheptanoid curcumin. In gastrointestinal tumor cells, sildenafil and curcumin… read more here.
Keywords: reactive oxygen; curcumin sildenafil; tumor cells; curcumin ... See more keywords