HIV-1 Reservoir Persistence and Decay: Implications for Cure Strategies
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DOI: 10.1007/s11904-022-00604-2
Abstract: Despite suppressive antiretroviral therapy (ART), a viral reservoir persists in individuals living with HIV that can reignite systemic replication should treatment be interrupted. Understanding how HIV-1 persists through effective ART is essential to develop cure… read more here.
Keywords: reservoir; persistence; cure strategies; hiv reservoir ... See more keywords
WHIM syndrome: Immunopathogenesis, treatment and cure strategies
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DOI: 10.1111/imr.12719
Abstract: WHIM syndrome is a rare, autosomal dominant immunodeficiency which is named for the four key manifestations: Warts, Hypogammaglobulinemia, Infections, and Myelokathexis. It results from heterozygous gain‐of‐function mutations in the chemokine receptor CXCR4 which is widely… read more here.
Keywords: syndrome immunopathogenesis; whim syndrome; immunopathogenesis treatment; cure strategies ... See more keywords
Measuring the Success of HIV-1 Cure Strategies
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00134
Abstract: HIV-1 eradication strategies aim to achieve viral remission in the absence of antiretroviral therapy (ART). The development of an HIV-1 cure remains challenging due to the latent reservoir (LR): long-lived CD4 T cells that harbor… read more here.
Keywords: cure strategies; hiv cure; cure; measuring success ... See more keywords