Dimerization energetics of curli fiber subunits CsgA and CsgB
Sign Up to like & getrecommendations! Published in 2019 at "npj Computational Materials"
DOI: 10.1038/s41524-019-0164-5
Abstract: Curli fibers are functional amyloids that exhibit strong adhesion and robust self-assembly as biofilm structural components; however, the binding energetics and mechanical properties of wild-type curli are not well understood. To address this, we present… read more here.
Keywords: subunits csga; curli; csga; csga csgb ... See more keywords
Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.10.20.513119
Abstract: In this work, the authors show that the phase separation of a cell surface-associated protein called CsgF is critical to mediate the secretion and assembly of the amyloidogenic curli subunits. Curli are functional amyloids present… read more here.
Keywords: csgf; secretion; curli; cell surface ... See more keywords
Regulation by cyclic di-GMP attenuates dynamics and enhances robustness of bimodal curli gene activation in Escherichia coli
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010750
Abstract: Curli amyloid fibers are a major constituent of the extracellular biofilm matrix formed by bacteria of the Enterobacteriaceae family. Within Escherichia coli biofilms, curli gene expression is limited to a subpopulation of bacteria, leading to… read more here.
Keywords: curli gene; curli; gene expression; gene ... See more keywords
Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010742
Abstract: Deposition of human amyloids is associated with complex human diseases such as Alzheimer’s and Parkinson’s. Amyloid proteins are also produced by bacteria. The bacterial amyloid curli, found in the extracellular matrix of both commensal and… read more here.
Keywords: dna; mature curli; curli fibrils; curli ... See more keywords
Microbiome or Infections: Amyloid-Containing Biofilms as a Trigger for Complex Human Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.638867
Abstract: The human microbiota is the community of microorganisms that live upon or within their human host. The microbiota consists of various microorganisms including bacteria, fungi, viruses, and archaea; the gut microbiota is comprised mostly of… read more here.
Keywords: complex human; curli; extracellular matrix; human amyloids ... See more keywords
Absence of Curli in Soil-Persistent Escherichia coli Is Mediated by a C-di-GMP Signaling Defect and Suggests Evidence of Biofilm-Independent Niche Specialization
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01340
Abstract: Escherichia coli is commonly viewed as a gastrointestinal commensal or pathogen although an increasing body of evidence suggests that it can persist in non-host environments as well. Curli are a major component of biofilm in… read more here.
Keywords: escherichia coli; soil; soil persistent; curli ... See more keywords
Antibodies against HSV-1 and Curli Show the Highest Correlation in Parkinson’s Disease Patients in Comparison to Healthy Controls
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314816
Abstract: Parkinson’s disease (PD) is a neurodegenerative disorder involving the accumulation of alpha-synuclein (α-syn)/Lewy bodies in the brain and -enteric nervous system. The etiology of the disease is not well understood, but bacterial and viral infections… read more here.
Keywords: disease; curli; healthy controls; parkinson disease ... See more keywords