Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.05.003
Abstract: &NA; Repeated activation of N‐Methyl‐D‐aspartate receptors (NMDARs) causes a Ca2+‐dependent reduction in NMDAR‐mediated current in dopamine (DA) neurons of the substantia nigra pars compacta (SNc) in one week old rats; however, a Ca2+‐dependent regulatory protein… read more here.
Keywords: nmdar current; ca2 dependent; calpain; current rundown ... See more keywords
Dissecting the Molecular Determinants of GABAA Receptors Current Rundown, a Hallmark of Refractory Human Epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Brain Sciences"
DOI: 10.3390/brainsci11040441
Abstract: GABAA receptors-(Rs) are fundamental for the maintenance of an efficient inhibitory function in the central nervous system (CNS). Their dysfunction is associated with a wide range of CNS disorders, many of which characterized by seizures… read more here.
Keywords: epilepsy; molecular determinants; current rundown; gabaa current ... See more keywords