Altered hippocampal volume and functional connectivity in patients with Cushing's disease
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2507
Abstract: Stress‐related brain disorders can be associated with glucocorticoid disturbance and hippocampal alteration. However, it remains largely unknown how cortisol affects the structure and function of hippocampus. Cushing's disease (CD) provides a unique “hyperexpression model” to… read more here.
Keywords: disease; hippocampal volume; volume functional; functional connectivity ... See more keywords
Effects of cortisol on the heart: characterization of myocardial involvement in cushing's disease by longitudinal cardiac MRI T1 mapping
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.25374
Abstract: Cushing's disease (CD) is associated with alterations in cardiac geometry and function, shown to be reversible after treatment. Our aim was to study cortisol‐related changes in myocardial content in CD at baseline and after treatment… read more here.
Keywords: cushing disease; heart characterization; cortisol heart; effects cortisol ... See more keywords
Dysregulation of resting-state functional connectivity in patients with Cushing’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Neuroradiology"
DOI: 10.1007/s00234-019-02223-y
Abstract: PurposeTo explore the anatomical distance-dependent functional connectivity patterns in patients with active phase of Cushing’s disease (CD) and to evaluate the associations between hypercortisol exposure and regional normalized functional connectivity strengths (nFCSs).MethodsBased on the fMRI… read more here.
Keywords: cushing disease; cortex; connectivity; resting state ... See more keywords
Long-term outcome of trans-sphenoidal surgery for Cushing’s disease in Indian patients
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-018-3736-0
Abstract: BackgroundThe results of trans-sphenoidal surgery (TSS) in Cushing’s disease (CD) vary widely depending upon patient characteristics as well as surgical experience. Patients in India are often referred late to referral centers. We studied the rates… read more here.
Keywords: cushing disease; sphenoidal surgery; long term; tss ... See more keywords
Pasireotide—a novel somatostatin receptor ligand after 20 years of use
Sign Up to like & getrecommendations! Published in 2022 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-022-09710-3
Abstract: Pasireotide, a novel multireceptor-targeted somatostatin receptor ligand (SRL) is characterized by a higher affinity to somatostatin receptor type 5 than type 2, unlike first-generation SRLs. Because of the broader binding profile, pasireotide has been suggested… read more here.
Keywords: somatostatin receptor; pasireotide novel; receptor ligand; cushing disease ... See more keywords
Pasireotide versus pituitary surgery: a retrospective analysis of 12 months of treatment in patients with Cushing’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1276-7
Abstract: Pituitary surgery represents the first-line treatment for most patients with Cushing’s disease (CD) [1, 2]. In the case of surgery failure, additional treatment options are required [3–6]. Pasireotide has shown favourable results in the first-line… read more here.
Keywords: cushing disease; surgery; treatment; treatment patients ... See more keywords
Microsurgical therapy of pituitary adenomas
Sign Up to like & getrecommendations! Published in 2017 at "Endocrine"
DOI: 10.1007/s12020-017-1458-3
Abstract: PurposeWe report the efficacy and safety of transsphenoidal microsurgery in a large and homogeneous cohort of patients with pituitary adenomas (PAs) treated at a single Institute by a single neurosurgeon.MethodsA total of 2145 consecutive patients… read more here.
Keywords: cushing disease; microsurgical therapy; tsh secreting; pituitary adenomas ... See more keywords
The medical treatment with pasireotide in Cushing’s disease: an Italian multicentre experience based on “real-world evidence”
Sign Up to like & getrecommendations! Published in 2018 at "Endocrine"
DOI: 10.1007/s12020-018-1818-7
Abstract: A phase III study has demonstrated that 6-month pasireotide treatment induced disease control with good safety in 15–26% of patients with Cushing’s disease (CD). The aim of the current study was to evaluate the 6-month… read more here.
Keywords: cushing disease; real world; world evidence; treatment ... See more keywords
Insulin sensitivity and secretion and adipokine profile in patients with Cushing’s disease treated with pasireotide
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-018-0839-7
Abstract: PurposeTo evaluate the effect of pasireotide on β-cell and adipose function in patients with Cushing’s disease (CD).MethodsClinical and hormonal parameters, insulin secretion evaluated by HOMA-β and by the area under the curve (AUC2h) of C-peptide… read more here.
Keywords: insulin; cushing disease; secretion; patients cushing ... See more keywords
Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-019-01151-1
Abstract: Background First-line therapy of Cushing disease (CD) is transsphenoidal surgery (TSS) aimed to obtain a complete removal of the pituitary adenoma and remission of disease. Purpose To analyse the surgical outcome of patients with CD… read more here.
Keywords: cushing disease; transsphenoidal surgery; remission; disease ... See more keywords
Pneumocystis pneumonia can complicate medical treatment of hypercortisolism even in outpatients with Cushing's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2020.11.002
Abstract: Several cases of Pneumocystosis pneumonia (PCP) have been reported, mainly in patients with severe ectopic ACTH syndrome (EAS). We report 2 cases of PCP that did not develop until after starting treatment with metyrapone, one of… read more here.
Keywords: cushing disease; medical treatment; treatment; hypercortisolism ... See more keywords