Cushing's syndrome mutant PKAL205R exhibits altered substrate specificity
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12562
Abstract: The PKAL205R hotspot mutation has been implicated in Cushing's syndrome through hyperactive gain‐of‐function PKA signaling; however, its influence on substrate specificity has not been investigated. Here, we employ the Proteomic Peptide Library (ProPeL) approach to… read more here.
Keywords: mutant pkal205r; cushing syndrome; substrate specificity; syndrome mutant ... See more keywords
Cushing syndrome cardiomyopathy: an unusual manifestation of small‐cell lung cancer
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DOI: 10.1002/ehf2.12860
Abstract: Cushing syndrome is a rare cause of dilated cardiomyopathy and heart failure with reduced ejection fraction. Cases describing this association are scarce. We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia,… read more here.
Keywords: syndrome cardiomyopathy; cell lung; cushing syndrome; lung cancer ... See more keywords
Ectopic Cushing’s syndrome due to thymic neuroendocrine tumours: a systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-021-09660-2
Abstract: Knowledge of ectopic Cushing’s syndrome (CS) due to thymic neuroendocrine tumours (NETs) comes from short series or single cases. Our aim is to perform a systematic review using PubMed, Embase, Scopus, Ovid Medline and Biosis… read more here.
Keywords: due thymic; thymic neuroendocrine; ectopic cushing; cushing syndrome ... See more keywords
Do the diagnostic criteria for subclinical hypercortisolism exist?
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2018.03.013
Abstract: "Subclinical hypercortisolism" (SH) refers to a condition associated with a mild chronic increase in cortisol secretion. By definition, patients with SH do not exhibit specific symptoms of overt Cushing's syndrome (such as purple striae, easy… read more here.
Keywords: hypercortisolism exist; criteria subclinical; hypercortisolism; cushing syndrome ... See more keywords
The difficulties of pseudo-Cushing's syndrome (or "non-neoplastic hypercortisolism").
Sign Up to like & getrecommendations! Published in 2018 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2018.04.017
Abstract: Pseudo-Cushing's syndrome covers different pathological conditions responsible for mild-to-moderate ACTH-dependent hypercortisolism, related not to an ACTH-secreting tumor but rather to CRH and/or AVP hypothalamic secretion through activation of various neural pathways, in patients generally displaying… read more here.
Keywords: neoplastic hypercortisolism; difficulties pseudo; hypercortisolism; cushing syndrome ... See more keywords
L'impact du syndrome de Cushing sur la fertilité et la grossesse.
Sign Up to like & getrecommendations! Published in 2022 at "Annales d'endocrinologie"
DOI: 10.1016/j.ando.2022.04.001
Abstract: Cushing's syndrome is defined by an endogenous or exogenous hypercortisolism. Increased cortisol, as well as increased androgens will have a negative impact on the pulsatile secretion of GnRH, thus leading to an increased risk of… read more here.
Keywords: hypercortisolism; syndrome cushing; syndrome; pregnancy ... See more keywords
Morbidity of Cushing's Syndrome and Impact of Treatment.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2018.01.001
Abstract: Cortisol excess in Cushing's syndrome is associated with metabolic, cardiovascular, and cognitive alterations, only partially reversible after resolution of hypercortisolism. Elevated cardiovascular risk may persist after eucortisolism has been achieved. Fractures and low bone mineral… read more here.
Keywords: syndrome impact; endocrinology; morbidity cushing; cushing syndrome ... See more keywords
Pregnancy in Patients with Cushing's Syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2018.02.004
Abstract: Progress in diagnosis and treatment of endocrine diseases has made pregnancy possible for women with endocrinopathies, including Cushing's syndrome (CS). The risk of maternal-fetal complications in patients who are not biochemically controlled, however, is substantial.… read more here.
Keywords: pregnancy; endocrinology; patients cushing; cushing syndrome ... See more keywords
Cushing's Syndrome 2018: Best Practices and Looking Ahead.
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology and metabolism clinics of North America"
DOI: 10.1016/j.ecl.2018.03.001
Abstract: Endogenous Cushing syndrome is a rare endocrine disorder with serious health implications. The July 2018 Endocrinology and Metabolism Clinics of North America issue is an update on pathogenesis, diagnosis, management, and prognosis of this challenging… read more here.
Keywords: cushing disease; endocrinology; 2018 best; best practices ... See more keywords
Hypertension and Cardiovascular Mortality in Patients with Cushing Syndrome.
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DOI: 10.1016/j.ecl.2019.08.005
Abstract: Patients with Cushing syndrome have an increased mortality rate, primarily due to increased cardiovascular death, which is driven by hypertension, diabetes, obesity, and dyslipidemia. These should be evaluated before and after active hypercortisolism, and each… read more here.
Keywords: hypertension cardiovascular; cushing syndrome; cardiovascular mortality; patients cushing ... See more keywords
Usefulness of ethomidate in patients with Cushing syndrome with severe arterial hypertension and hypopotassemia.
Sign Up to like & getrecommendations! Published in 2017 at "Medicina Intensiva"
DOI: 10.1016/j.medine.2016.05.005
Abstract: 2. Chandra SR, Seshadri R, Chikabasaviah Y, Issac TG. Progressive limbic encephalopathy: problems and prospects. Ann Indian Acad Neurol. 2014;17:166--70. 3. Tuzün E, Dalmau J. Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist. 2007;13:261--71.… read more here.
Keywords: ethomidate patients; patients cushing; usefulness ethomidate; cushing syndrome ... See more keywords