Concerted cutting by Spo11 illuminates meiotic DNA break mechanics.
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DOI: 10.1038/s41586-021-03389-3
Abstract: Genetic recombination arises during meiosis through the repair of DNA double-strand breaks (DSBs) that are created by Spo11, a topoisomerase-like protein1,2. Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots3,4, yet how Spo11 engages with… read more here.
Keywords: dna; cutting spo11; concerted cutting; spo11 dsbs ... See more keywords