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   Articles with "cvb3" as a keyword



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Novel recombinant coxsackievirus B3 with genetically inserted basic peptide elicits robust antitumor activity against lung cancer

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recommendations! Published in 2020 at "Cancer Medicine"

DOI: 10.1002/cam4.3143

Abstract: Cancer therapy that utilizes oncolytic virus may offer an exciting alternative, and coxsackievirus B3 (CVB3) is a potent oncolytic virus. This study was to assess the oncolytic activities of novel recombinant CVB3 with genetically inserted… read more here.

Keywords: inserted basic; cvb3; cancer; genetically inserted ... See more keywords
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The protection effects of survivin in the cell model of CVB3-induced viral myocarditis

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recommendations! Published in 2020 at "Heart and Vessels"

DOI: 10.1007/s00380-020-01607-y

Abstract: Viral myocarditis (VMC) is a widely studied but poorly understood inflammatory cardiomyopathy which mainly affects children and young adults and results in adverse outcomes. Cardiomyocyte apoptosis was reported important in the progress of coxsackievirus B3… read more here.

Keywords: caspase; cvb3 induced; survivin; cell model ... See more keywords
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New class of early‐stage enterovirus inhibitors with a novel mechanism of action

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recommendations! Published in 2017 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2017.10.004

Abstract: Abstract 4‐dimethylamino benzoic acid (compound 12, synonym: 4EDMAB) was identified as an in vitro inhibitor of Coxsackie virus B3 (CVB3) replication in CPE‐based assays (EC50 of 9.1 ± 1.5 &mgr;M). Next, the activity of twenty‐three… read more here.

Keywords: mechanism; early stage; compound; cvb3 ... See more keywords
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V&ggr;1+&ggr;&dgr;T, early cardiac infiltrated innate population dominantly producing IL‐4, protect mice against CVB3 myocarditis by modulating IFN&ggr;+ T response

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recommendations! Published in 2017 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2016.11.006

Abstract: HighlightsCardiac V&ggr;1 + &ggr;&dgr;T cells infiltration peaked on day3 post CVB3 infection.V&ggr;1 + &ggr;&dgr;T cells represent a dominant early source for IL‐4 in the heart.V&ggr;1 + &ggr;&dgr;T cells suppress CVB3‐induced acute cardiac inflammation via IL‐4.V&ggr;1… read more here.

Keywords: ggr ggr; dgr cells; ggr; cvb3 ... See more keywords
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Peracetic acid (PAA) and low-pressure ultraviolet (LP-UV) inactivation of Coxsackievirus B3 (CVB3) in municipal wastewater individually and concurrently.

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recommendations! Published in 2020 at "Water research"

DOI: 10.1016/j.watres.2020.116048

Abstract: Domestic wastewater (WW) contains a large number of pathogenic viruses that are not significantly reduced in most WW treatment processes and are found in high numbers in the effluent of conventionally disinfected WW. In this… read more here.

Keywords: peracetic acid; disinfection; efficacy; wastewater ... See more keywords
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Luteolin inhibits CVB3 replication through inhibiting inflammation

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recommendations! Published in 2019 at "Journal of Asian Natural Products Research"

DOI: 10.1080/10286020.2019.1642329

Abstract: Abstract Coxsackievirus B3 (CVB3) infection causes many inflammation-related diseases, such as viral myocarditis and aseptic meningitis. However, no vaccines or drugs have been approved for prevention or therapy of CVB3-induced diseases. In this study, luteolin… read more here.

Keywords: inhibiting inflammation; inflammation; luteolin inhibits; inhibits cvb3 ... See more keywords
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Transient atrial inflammation in a murine model of Coxsackievirus B3‐induced myocarditis

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recommendations! Published in 2022 at "International Journal of Experimental Pathology"

DOI: 10.1111/iep.12438

Abstract: Atrial dysfunction is a relatively common complication of acute myocarditis, although its pathophysiology is unclear. There is limited information on myocarditis‐associated histological changes in the atria and how they develop in time. The aim of… read more here.

Keywords: myocarditis; inflammation; transient atrial; cvb3 ... See more keywords

Cardiomyocyte-derived HMGB1 takes a protective role in CVB3-induced viral myocarditis via inhibiting cardiac apoptosis.

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recommendations! Published in 2023 at "Immunology and cell biology"

DOI: 10.1111/imcb.12660

Abstract: Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) is characterized by immune cell infiltration and myocardial damage. High mobility group box 1 (HMGB1) is a highly conserved nuclear DNA-binding protein that participates in DNA replication, transcriptional regulation,… read more here.

Keywords: myocarditis; cardiomyocyte; cvb3; induced viral ... See more keywords
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Testosterone Promotes the Intestinal Replication and Dissemination of Coxsackievirus B3 in an Oral Inoculation Mouse Model

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recommendations! Published in 2022 at "Journal of Virology"

DOI: 10.1128/jvi.01232-22

Abstract: Biological sex plays a significant role in the outcomes of various infections and diseases. The impact of sex hormones on the intestinal replication and dissemination of Coxsackievirus B3 remains poorly understood. ABSTRACT Enteroviruses initiate infection… read more here.

Keywords: replication; cvb3; intestinal replication; sex ... See more keywords
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Persistent Coxsackievirus B3 Infection in Pancreatic Ductal Cells In Vitro Downregulates Cellular Polyamine Metabolism

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recommendations! Published in 2023 at "mSphere"

DOI: 10.1128/msphere.00036-23

Abstract: Enteroviruses are significant human pathogens that can cause severe disease, including cardiomyopathies. Viruses like coxsackievirus B3 (CVB3) can cause tissue damage by lytically infecting cells; however, CVB3 can also persistently infect, which has been associated… read more here.

Keywords: infection; infection pancreatic; cvb3; coxsackievirus ... See more keywords
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B-arrestin deletion abrogates the innate immune response in murine CVB3 myocarditis

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recommendations! Published in 2023 at "Physiology"

DOI: 10.1152/physiol.2023.38.s1.5731432

Abstract: β-arrestins (βarrs), initially discovered as desensitizers of GPCR signaling, are now known to function as intracellular scaffolds and signaling transducers mediating a wide array of signaling cascades including immune responses to inflammatory stimuli. An important… read more here.

Keywords: myocarditis; immune cell; cvb3; physiology ... See more keywords