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   Articles with "cvb3" as a keyword



Novel recombinant coxsackievirus B3 with genetically inserted basic peptide elicits robust antitumor activity against lung cancer

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recommendations! Published in 2020 at "Cancer Medicine"

DOI: 10.1002/cam4.3143

Abstract: Cancer therapy that utilizes oncolytic virus may offer an exciting alternative, and coxsackievirus B3 (CVB3) is a potent oncolytic virus. This study was to assess the oncolytic activities of novel recombinant CVB3 with genetically inserted… read more here.

Keywords: inserted basic; cvb3; cancer; genetically inserted ... See more keywords

The protection effects of survivin in the cell model of CVB3-induced viral myocarditis

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recommendations! Published in 2020 at "Heart and Vessels"

DOI: 10.1007/s00380-020-01607-y

Abstract: Viral myocarditis (VMC) is a widely studied but poorly understood inflammatory cardiomyopathy which mainly affects children and young adults and results in adverse outcomes. Cardiomyocyte apoptosis was reported important in the progress of coxsackievirus B3… read more here.

Keywords: caspase; cvb3 induced; survivin; cell model ... See more keywords

New class of early‐stage enterovirus inhibitors with a novel mechanism of action

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recommendations! Published in 2017 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2017.10.004

Abstract: Abstract 4‐dimethylamino benzoic acid (compound 12, synonym: 4EDMAB) was identified as an in vitro inhibitor of Coxsackie virus B3 (CVB3) replication in CPE‐based assays (EC50 of 9.1 ± 1.5 &mgr;M). Next, the activity of twenty‐three… read more here.

Keywords: mechanism; early stage; compound; cvb3 ... See more keywords

V&ggr;1+&ggr;&dgr;T, early cardiac infiltrated innate population dominantly producing IL‐4, protect mice against CVB3 myocarditis by modulating IFN&ggr;+ T response

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recommendations! Published in 2017 at "Molecular Immunology"

DOI: 10.1016/j.molimm.2016.11.006

Abstract: HighlightsCardiac V&ggr;1 + &ggr;&dgr;T cells infiltration peaked on day3 post CVB3 infection.V&ggr;1 + &ggr;&dgr;T cells represent a dominant early source for IL‐4 in the heart.V&ggr;1 + &ggr;&dgr;T cells suppress CVB3‐induced acute cardiac inflammation via IL‐4.V&ggr;1… read more here.

Keywords: ggr ggr; dgr cells; ggr; cvb3 ... See more keywords

Peracetic acid (PAA) and low-pressure ultraviolet (LP-UV) inactivation of Coxsackievirus B3 (CVB3) in municipal wastewater individually and concurrently.

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recommendations! Published in 2020 at "Water research"

DOI: 10.1016/j.watres.2020.116048

Abstract: Domestic wastewater (WW) contains a large number of pathogenic viruses that are not significantly reduced in most WW treatment processes and are found in high numbers in the effluent of conventionally disinfected WW. In this… read more here.

Keywords: peracetic acid; disinfection; efficacy; wastewater ... See more keywords

Synergistic Viro-chemoimmunotherapy in Breast Cancer Enabled by Bioengineered Immunostimulatory Exosomes and Dual-Targeted Coxsackievirus B3

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recommendations! Published in 2024 at "ACS Nano"

DOI: 10.1021/acsnano.3c09491

Abstract: Breast cancer’s immunosuppressive environment hinders effective immunotherapy, but oncolytic viruses hold promise for addressing this challenge by targeting tumor cells and altering the microenvironment. Yet, neutralizing antibodies and immune clearance impede their clinical utility. This… read more here.

Keywords: cancer; breast cancer; exomir cvb3; mir cvb3 ... See more keywords

Targeting Viperin prevents coxsackievirus B3-induced acute heart failure

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recommendations! Published in 2025 at "Cell Discovery"

DOI: 10.1038/s41421-025-00778-0

Abstract: Coxsackievirus B3 (CVB3)-induced acute heart failure (AHF) is a common cause of cardiogenic death in young- and middle-aged people. However, the key molecular events linking CVB3 to AHF remain largely unknown, resulting in a lack… read more here.

Keywords: viperin; cvb3 induced; induced acute; heart failure ... See more keywords

Luteolin inhibits CVB3 replication through inhibiting inflammation

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recommendations! Published in 2019 at "Journal of Asian Natural Products Research"

DOI: 10.1080/10286020.2019.1642329

Abstract: Abstract Coxsackievirus B3 (CVB3) infection causes many inflammation-related diseases, such as viral myocarditis and aseptic meningitis. However, no vaccines or drugs have been approved for prevention or therapy of CVB3-induced diseases. In this study, luteolin… read more here.

Keywords: inhibiting inflammation; inflammation; luteolin inhibits; inhibits cvb3 ... See more keywords

Innovative use of gram-positive enhancer matrix particles and affinity peptides in a vaccine against Coxsackievirus B3

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recommendations! Published in 2025 at "Virulence"

DOI: 10.1080/21505594.2025.2481657

Abstract: ABSTRACT Viral myocarditis (VM) is an inflammatory disease posing a serious threat to public health, with various viral pathogens contributing to its pathogenesis. Coxsackievirus B3 (CVB3) is the most frequently implicated causative agent and has… read more here.

Keywords: gram positive; gem vp1; gem; vaccine ... See more keywords

A new hiPSC-based viral expression system to study virus host-cell interaction in hiPSC-derived cardiomyocytes

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recommendations! Published in 2024 at "Europace"

DOI: 10.1093/europace/euae102.613

Abstract: Abstract Coxsackievirus B3 (CVB3) belongs to the Picornaviridae family and is a member of the enterovirus genus. CVB3 is the most frequently detected pathogen in viral myocarditis, which leads to acute heart infections in 20-40%… read more here.

Keywords: system; culture; virus; cell ... See more keywords

Transient atrial inflammation in a murine model of Coxsackievirus B3‐induced myocarditis

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recommendations! Published in 2022 at "International Journal of Experimental Pathology"

DOI: 10.1111/iep.12438

Abstract: Atrial dysfunction is a relatively common complication of acute myocarditis, although its pathophysiology is unclear. There is limited information on myocarditis‐associated histological changes in the atria and how they develop in time. The aim of… read more here.

Keywords: myocarditis; inflammation; transient atrial; cvb3 ... See more keywords