The protection effects of survivin in the cell model of CVB3-induced viral myocarditis
Sign Up to like & getrecommendations! Published in 2020 at "Heart and Vessels"
DOI: 10.1007/s00380-020-01607-y
Abstract: Viral myocarditis (VMC) is a widely studied but poorly understood inflammatory cardiomyopathy which mainly affects children and young adults and results in adverse outcomes. Cardiomyocyte apoptosis was reported important in the progress of coxsackievirus B3… read more here.
Keywords: caspase; cvb3 induced; survivin; cell model ... See more keywords
Expansion of CD11b+Ly‐6C+ myeloid‐derived suppressor cells (MDSCs) driven by galectin‐9 attenuates CVB3‐induced myocarditis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.01.013
Abstract: &NA; Galectin‐9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3‐induced myocarditis. In the present study, we found that galectin‐9 induced the expansion of CD11b+Ly‐6C+ myeloid‐derived suppressor… read more here.
Keywords: expansion cd11b; cvb3 induced; induced myocarditis; cd11b ... See more keywords
Targeting Viperin prevents coxsackievirus B3-induced acute heart failure
Sign Up to like & getrecommendations! Published in 2025 at "Cell Discovery"
DOI: 10.1038/s41421-025-00778-0
Abstract: Coxsackievirus B3 (CVB3)-induced acute heart failure (AHF) is a common cause of cardiogenic death in young- and middle-aged people. However, the key molecular events linking CVB3 to AHF remain largely unknown, resulting in a lack… read more here.
Keywords: viperin; cvb3 induced; induced acute; heart failure ... See more keywords
MTHFD2 orchestrates monocyte-macrophage immune homeostasis by targeting Rap1 to protect against CVB3-induced viral myocarditis.
Sign Up to like & getrecommendations! Published in 2025 at "Cardiovascular research"
DOI: 10.1093/cvr/cvaf227
Abstract: AIMS Pro-inflammatory macrophages are critical mediators of the viral myocarditis (VMC) pathological process. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a key enzyme involved in one-carbon metabolism, plays an essential regulatory role in macrophage function. However, the regulatory… read more here.
Keywords: mice; cvb3 induced; monocyte macrophage; macrophage ... See more keywords
Cardiomyocyte-derived HMGB1 takes a protective role in CVB3-induced viral myocarditis via inhibiting cardiac apoptosis.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology and cell biology"
DOI: 10.1111/imcb.12660
Abstract: Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC) is characterized by immune cell infiltration and myocardial damage. High mobility group box 1 (HMGB1) is a highly conserved nuclear DNA-binding protein that participates in DNA replication, transcriptional regulation,… read more here.
Keywords: myocarditis; cardiomyocyte; cvb3; induced viral ... See more keywords
Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via α3β4-nAChR/PI3K/Akt-Dependent Survivin Upregulation
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/9496419
Abstract: Background Cardiomyocyte apoptosis is critical for the development of coxsackievirus B3- (CVB3-) induced myocarditis, which is a common cardiac disease that may result in heart failure or even sudden death. Previous studies have associated CVB3-induced… read more here.
Keywords: cvb3 induced; apoptosis; survivin; induced myocarditis ... See more keywords
The Severity of CVB3-Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice
Sign Up to like & getrecommendations! Published in 2021 at "Mediators of Inflammation"
DOI: 10.1155/2021/5551578
Abstract: Background The functional characteristics of NLRP3 in the pathogenesis of coxsackievirus B3- (CVB3-) induced viral myocarditis (VMC) have not been fully elucidated, and the targeted therapeutic effect of NLRP3 or its related pathway in VMC… read more here.
Keywords: th17; cvb3 induced; balb; nlrp3 th17 ... See more keywords
CVB3-induced P62 cleavage promotes ferroptosis through the NRF2/GPX4 axis and facilitates viral replication
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1675667
Abstract: Introduction Coxsackievirus B3 (CVB3) represents a major etiological agent of viral myocarditis, whose propagation within host organs results in substantial tissue injury. The molecular pathways through which CVB3 exerts its pathological effects, particularly its connection… read more here.
Keywords: cvb3 induced; gpx4; gpx4 axis; nrf2 gpx4 ... See more keywords
The PI3K/Akt/mTOR pathway is involved in CVB3-induced autophagy of HeLa cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2017.3008
Abstract: Recent studies have found that viral myocarditis (VMC) associated with coxsackievirus B3 (CVB3) causes autophagy activation after infection, but the specific mechanism is not clear. The present study demonstrated that the phosphatidylinositol 3-kinase (PI3K)/protein kinase… read more here.
Keywords: pi3k; cvb3 induced; infection; mtor ... See more keywords
The regulatory role of Sigmar1 in CVB3-induced myocarditis.
Sign Up to like & getrecommendations! Published in 2025 at "General physiology and biophysics"
DOI: 10.4149/gpb_2025011
Abstract: Sigma-1 receptor (Sigmar1) is associated with endoplasmic reticulum (ER) stress. This study investigated whether Sigmar1 affect myocarditis progression via Coxsackievirus B3 (CVB3)-caused ER stress. Neonatal mouse cardiomyocytes (NMCs) were transfected with Sigmar1 and/or stress-induced phosphoprotein… read more here.
Keywords: sigmar1; cvb3 induced; stub1 overexpression; cvb3 ... See more keywords