The Bioactive Phenolic Agents Diaryl Ether CVB2-61 and Diarylheptanoid CVB4-57 as Connexin Hemichannel Blockers
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DOI: 10.3390/ph15101173
Abstract: Inflammation mediators enhance the activity of connexin (Cx) hemichannels, especially in the epithelial and endothelial tissues. As potential release routes for injury signals, such as (oligo)nucleotides, Cx hemichannels may contribute to long-lasting inflammation. Specific inhibition… read more here.
Keywords: phenolic agents; bioactive phenolic; cvb4; calu cells ... See more keywords
Genomic Epidemiology and Transmission Dynamics of Global Coxsackievirus B4
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DOI: 10.3390/v15020569
Abstract: The aim of this study was to determine the global genetic diversity and transmission dynamics of coxsackievirus B4 (CVB4) and to propose future directions for disease surveillance. Next-generation sequencing was performed to obtain the complete… read more here.
Keywords: cvb4; epidemiology transmission; genomic epidemiology; epidemiology ... See more keywords
A Monovalent Mt10-CVB3 Vaccine Prevents CVB4-Accelerated Type 1 Diabetes in NOD Mice
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DOI: 10.3390/vaccines11010076
Abstract: Enteroviruses, which include Coxsackieviruses, are a common cause of virus infections in humans, and multiple serotypes of the group B Coxsackievirus (CVB) can induce similar diseases. No vaccines are currently available to prevent CVB infections… read more here.
Keywords: nod mice; cvb4; type diabetes; cvb3 vaccine ... See more keywords