Connexin 32 deficiency protects the liver against ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173056
Abstract: Hepatic ischemia/reperfusion (I/R) injury is a common complication in the clinical setting. Our previous study has shown that connexin 32 (Cx32) plays a major role in renal I/R injury; however, the role of Cx32 in… read more here.
Keywords: connexin; cx32; reperfusion injury; ischemia reperfusion ... See more keywords
Cx32 hemichannel opening by cytosolic Ca2+ is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease
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DOI: 10.1093/hmg/ddx386
Abstract: Mutations of the GJB1 gene encoding connexin 32 (Cx32) cause the X-linked form of Charcot-Marie-Tooth disease (CMTX1), a demyelinating peripheral neuropathy for which there is no cure. A growing body of evidence indicates that ATP… read more here.
Keywords: hemichannel opening; cx32; charcot marie; cytosolic ca2 ... See more keywords
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked Nox4 polyubiquitination and degradation via the inhibition of Smurf1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14853
Abstract: BACKGROUND AND PURPOSE Nox4 is the major NADPH isoform in the kidney and contributes to the pathogenesis of diabetic nephropathy (DN). However, the molecular mechanisms of increased Nox4 expression induced by hyperglycaemia remain to be… read more here.
Keywords: fibrosis; k48 linked; cx32; expression ... See more keywords
Connexin 32 downregulation is critical for chemoresistance in oxaliplatin-resistant HCC cells associated with EMT
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s203656
Abstract: Background: Oxaliplatin (OXA)-based chemotherapy is critical in the management of advanced hepatocellular carcinoma (HCC); however, acquired drug resistance has largely restricted its clinical efficacy. This study aims to explore the key mechanisms and regulatory factors… read more here.
Keywords: hcc; hcc cells; resistant hcc; cx32 ... See more keywords
Connexin Mutations and Hereditary Diseases
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DOI: 10.3390/ijms23084255
Abstract: Inherited diseases caused by connexin mutations are found in multiple organs and include hereditary deafness, congenital cataract, congenital heart diseases, hereditary skin diseases, and X-linked Charcot–Marie–Tooth disease (CMT1X). A large number of knockout and knock-in… read more here.
Keywords: function; pathology; mutations hereditary; cx32 ... See more keywords
Cx32 promotes autophagy and produces resistance to SN‑induced apoptosis via activation of AMPK signalling in cervical cancer.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2021.5300
Abstract: The roles of gap junctions (GJs) and its components, connexins, in the autophagy of cervical cancer cells have been rarely investigated. Our previous study demonstrated that connexin 32 (Cx32) exerted an anti‑apoptotic effect on cervical cancer.… read more here.
Keywords: cervical cancer; cancer; cancer cells; cx32 ... See more keywords
Connexin32 regulates expansion of liver cancer stem cells via the PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Reports"
DOI: 10.3892/or.2022.8381
Abstract: Liver cancer stem cells (LCSCs) are responsible for liver cancer recurrence, metastasis, and drug resistance. Previous studies by the authors demonstrated that upregulated expression of connexin 32 (Cx32) reversed doxorubicin resistance and reduced invasion and… read more here.
Keywords: expansion; pi3k akt; cx32; liver cancer ... See more keywords