Astragaloside IV ameliorates cerebral ischemia-reperfusion injury via upregulation of PKA and Cx36
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DOI: 10.1097/wnr.0000000000001831
Abstract: Objectives To determine the effects of astragaloside IV on cerebral ischemic-reperfusion injury in rats and to explore underlying mechanisms of brain protection. Methods Sixty Sprague–Dawley rats were randomized into four groups: Sham, cerebral ischemia-reperfusion (I/R… read more here.
Keywords: cx36; reperfusion; pka; cerebral ischemia ... See more keywords
Upregulation of connexins in the rat hippocampal and cortical neurons following blockade of NMDA receptors during postnatal development.
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DOI: 10.2174/0929866530666221024153723
Abstract: BACKGROUND Interneural gap junctional coupling is a representation of neural development that decreases during the postnatal period. The decrease of gap junctions function coincides with the main period of chemical synapse creation and increment of… read more here.
Keywords: hippocampal cortical; blockade nmda; cx36; nmda receptors ... See more keywords
Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis
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DOI: 10.3389/fnins.2018.00894
Abstract: Connexin36 (Cx36) forms gap junctions between neurons, which are called electrical synapses, enabling adjacent neurons to communicate directly. The participation of chemical synapses in neurodegeneration in amyotrophic lateral sclerosis (ALS) has long been indicated, but… read more here.
Keywords: cx36; made electrical; neuronal dendritic; early stage ... See more keywords
Localization of Retinal Ca2+/Calmodulin-Dependent Kinase II-β (CaMKII-β) at Bipolar Cell Gap Junctions and Cross-Reactivity of a Monoclonal Anti-CaMKII-β Antibody With Connexin36
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DOI: 10.3389/fnmol.2019.00206
Abstract: Neuronal gap junctions formed by connexin36 (Cx36) and chemical synapses share striking similarities in terms of plasticity. Ca2+/calmodulin-dependent protein kinase II (CaMKII), an enzyme known to induce memory formation at chemical synapses, has recently been… read more here.
Keywords: cx36; gap junctions; bipolar cell; camkii ... See more keywords
Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes
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DOI: 10.3389/fphys.2022.913611
Abstract: In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca2+ homeostasis. Connexin36 (Cx36) gap junctions electrically couple β-cells to coordinate glucose-stimulated Ca2+ and insulin secretion.… read more here.
Keywords: cx36; junction coupling; gap junction; islet ... See more keywords