Total saponins of panax ginseng via the CX3CL1/CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild stress in rats
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7696
Abstract: Total saponins of Panax ginseng (TSPG) have antidepressant effects. However, the underlying antidepressant mechanism of TSPG remains not clear. This study aimed to predict the mechanism of TSPG by bioinformatics analysis and to verify it… read more here.
Keywords: total saponins; cx3cl1 cx3cr1; cx3cl1; saponins panax ... See more keywords
Clinical significance of expression level of CX3CL1–CX3CR1 axis in bone metastasis of lung cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-020-02431-6
Abstract: Purpose To investigate the clinical significance of CX3 chemokine ligand 1(CX3CL1) and CX3CR1 in patients with bone metastasis from lung cancer. The expression levels of CX3CL1 and CX3CR1 mRNA and protein in primary lung cancer… read more here.
Keywords: metastasis; cx3cl1 cx3cr1; bone metastasis; lung cancer ... See more keywords
Repopulating retinal microglia restore endogenous organization and function under CX3CL1-CX3CR1 regulation
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aap8492
Abstract: Chemokine signaling via CX3CL1-CX3CR1 helps regulate homeostasis in the population of microglia in the adult mouse retina. Microglia have been discovered to undergo repopulation following ablation. However, the functionality of repopulated microglia and the mechanisms… read more here.
Keywords: organization function; repopulation; cx3cl1 cx3cr1; cx3cr1 ... See more keywords
Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/5665964
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the… read more here.
Keywords: metastasis; pdac; liver metastasis; cx3cl1 cx3cr1 ... See more keywords
The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-020-01923-0
Abstract: Background The bidirectional communication between neurons and microglia is fundamental for the homeostasis and biological function of the central nervous system. Maternal immune activation (MIA) is considered to be one of the factors affecting these… read more here.
Keywords: cd200 cd200r; mia; cx3cl1 cx3cr1; cx3cr1 cd200 ... See more keywords
Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-018-0138-4
Abstract: BackgroundNeuron-microglia communication plays a crucial role in the motor neurons (MNs) death in amyotrophic lateral sclerosis (ALS). Neurons can express chemokine (C-X3-C motif) ligand 1 (CX3CL1), which mediates microglial activation via interacting with its sole… read more here.
Keywords: spinal cord; cx3cl1 cx3cr1; cx3cr1; microglial activation ... See more keywords
Structure and function of ligand CX3CL1 and its receptor CX3CR1 in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220629140540
Abstract: The C-X3-C motif chemokine ligand (CX3CL)1 (also known as Fractalkine) and its receptor CX3CR1 (also known as G-protein coupled receptor 13) are expressed on the membranes of many different cells such as epithelial cells, dendritic… read more here.
Keywords: receptor cx3cr1; cx3cl1 cx3cr1; ligand; cx3cr1 ... See more keywords
CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1189348
Abstract: Introduction Hypoxia-induced neuronal damage is the primary cause of cognitive impairment induced by high-altitude exposure. Microglia play a crucial regulatory role in the central nervous system (CNS) homeostasis and synaptic plasticity. M1-type polarized microglia are… read more here.
Keywords: cx3cr1 signal; cx3cl1 cx3cr1; hypoxia; high altitude ... See more keywords
Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1–CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11020464
Abstract: Allocryptopine (ALL) is an isoquinoline alkaloid extracted from Macleaya cordata (Willd). R. Br., which has been claimed to have anti-inflammatory and neuroprotection properties. However, the mechanism by which ALL ameliorates inflammatory bowel disease (IBD) remains… read more here.
Keywords: apoptosis; cx3cl1 cx3cr1; pharmacology; gnb5 ... See more keywords
Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2017.2969
Abstract: The present study aimed to explore the influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism (APE) in rats. Our previous study found that CX3CL1/CX3CR1 was increased in APE. However, the effect… read more here.
Keywords: group group; cx3cl1; group; signaling pathway ... See more keywords
Expression changes of CX3CL1 and CX3CR1 proteins in the hippocampal CA1 field of the gerbil following transient global cerebral ischemia
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2019.4273
Abstract: Chemokine C-X3-C motif ligand 1 (CX3CL1) and its sole receptor, CX3CR1, are known to be involved in neuronal damage/death following brain ischemia. In the present study, time-dependent expression changes of CX3CL1 and CX3CR1 proteins were… read more here.
Keywords: cx3cr1 proteins; expression changes; expression; changes cx3cl1 ... See more keywords