Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus
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DOI: 10.1038/mi.2017.63
Abstract: CX3CL1 has been implicated in allergen-induced airway CD4+ T-lymphocyte recruitment in asthma. As epidemiological evidence supports a viral infection–allergen synergy in asthma exacerbations, we postulated that rhinovirus (RV) infection in the presence of allergen augments… read more here.
Keywords: proteases cleave; cx3cl1; cx3cl1 shedding; allergenic proteases ... See more keywords