CX3CR1 regulates gut microbiota and metabolism. A risk factor of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Acta Diabetologica"
DOI: 10.1007/s00592-021-01682-1
Abstract: The intestinal microbiota to immune system crosstalk is a major regulator of metabolism and hence metabolic diseases. An impairment of the chemokine receptor CX3CR1, as a key regulator shaping intestinal microbiota under normal chow feeding,… read more here.
Keywords: metabolism; control; cx3cr1; gut microbiota ... See more keywords
Involvement of NF-κB and the CX3CR1 Signaling Network in Mechanical Allodynia Induced by Tetanic Sciatic Stimulation
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-017-0149-7
Abstract: Tetanic stimulation of the sciatic nerve (TSS) triggers long-term potentiation in the dorsal horn of the spinal cord and long-lasting pain hypersensitivity. CX3CL1–CX3CR1 signaling is an important pathway in neuronal–microglial activation. Nuclear factor κB (NF-κB)… read more here.
Keywords: cx3cr1 signaling; cx3cr1; allodynia induced; involvement cx3cr1 ... See more keywords
The Association Between BMP-2, UQCC1 and CX3CR1 Polymorphisms and the Risk of Developmental Dysplasia of the Hip.
Sign Up to like & getrecommendations! Published in 2021 at "Indian journal of orthopaedics"
DOI: 10.1007/s43465-020-00235-y
Abstract: Objective Developmental dysplasia of the hip (DDH) is a complicated skeletal disease ranging from subluxation to complete dislocation of the hip as a result of insufficient development of the acetabulum and femur. To date, numerous… read more here.
Keywords: ddh; bmp; hip; etiology ... See more keywords
Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages.
Sign Up to like & getrecommendations! Published in 2017 at "Immunobiology"
DOI: 10.1016/j.imbio.2016.07.013
Abstract: Mucosal immunity at the intestinal level is constantly challenged by the presence of external food and microbial antigens and must be kept under strict control to avoid the rise of aberrant inflammation. Among cells of… read more here.
Keywords: anti inflammatory; cx3cr1; role; receptor ... See more keywords
Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Oncogene"
DOI: 10.1038/s41388-021-02174-w
Abstract: Metastasis-initiating cells (MICs) display stem cell-like features, cause metastatic recurrences and defy chemotherapy, which leads to patients’ demise. Here we show that prostate and breast cancer patients harbor contingents of tumor cells with high expression… read more here.
Keywords: expressing cx3cr1; cancer cells; metastasis; cx3cr1 ... See more keywords
Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma
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DOI: 10.1038/s41389-018-0046-6
Abstract: Failure of currently used cytotoxic chemotherapy is one of the main reasons behind high mortality from metastatic high grade serous ovarian carcinoma. We found that high expression of a receptor for fractalkine (CX3CR1) significantly correlated… read more here.
Keywords: dna damage; ovarian carcinoma; cx3cr1; dna ... See more keywords
CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Research"
DOI: 10.1038/s41390-019-0677-0
Abstract: Background Data on the host factors that contribute to infection of young children by respiratory syncytial virus (RSV) are limited. The human chemokine receptor, CX3CR1, has recently been implicated as an RSV receptor. Here we… read more here.
Keywords: respiratory syncytial; syncytial virus; infection; cx3cr1 ... See more keywords
Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17007-8
Abstract: The potential role of macrophages in pulmonary fibrosis (PF) prompted us to evaluate the roles of CX3CR1, a chemokine receptor abundantly expressed in macrophages during bleomycin (BLM)-induced PF. Intratracheal BLM injection induced infiltration of leukocytes… read more here.
Keywords: fibrosis; cx3cr1; essential involvement; involvement cx3cl1 ... See more keywords
Ischemia-induced Neuronal Cell Death Is Mediated by Chemokine Receptor CX3CR1
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DOI: 10.1038/s41598-017-18774-0
Abstract: The chemokine fractalkine (CX3CL1) and its receptor CX3CR1 play a fundamental role in the pathophysiology of stroke. Previous studies have focused on a paracrine interaction between neurons that produce fractalkine and microglia that express CX3CR1… read more here.
Keywords: receptor cx3cr1; ischemia; cx3cr1; cell death ... See more keywords
CX3CR1 modulates the anti-inflammatory activity of hepatic dendritic cells in response to acute liver injury.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical science"
DOI: 10.1042/cs20171025
Abstract: The chemokine fractalkine (CX3CL1) and its receptor CX3CR1 are known to mediate leukocyte chemotaxis, adhesion and survival. In the liver, CX3CR1 is expressed on multiple cell types including monocytes and dendritic cells. However, the function… read more here.
Keywords: cx3cr1; gfp; dendritic cells; mice ... See more keywords
CX3CR1 Depletion Promotes the Formation of Platelet–Neutrophil Complexes and Aggravates Acute Peritonitis
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DOI: 10.1097/shk.0000000000001733
Abstract: Supplemental Digital Content is available in the text ABSTRACT Background: Peritonitis is a life-threatening condition on intensive care units. Inflammatory cytokines and their receptors drive inflammation, cause the formation of platelet–neutrophil complexes (PNCs) and therefore… read more here.
Keywords: expression; cx3cr1; formation; peritonitis ... See more keywords