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   Articles with "cx43" as a keyword



Connexin 43 upregulation by dioscin inhibits melanoma progression via suppressing malignancy and inducing M1 polarization

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recommendations! Published in 2017 at "International Journal of Cancer"

DOI: 10.1002/ijc.30872

Abstract: Connexin 43 (Cx43), a vital gap junction protein in tumor microenvironment (TME), is a novel molecular target for melanoma chemotherapeutics due to its tumor suppressive function. Dioscin, an herbal steroidal saponin, exerts anti‐tumor effects while… read more here.

Keywords: dioscin; malignancy; connexin upregulation; cx43 ... See more keywords
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Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down‐Regulating Connexin 43

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recommendations! Published in 2017 at "Phytotherapy Research"

DOI: 10.1002/ptr.5868

Abstract: Paeoniflorin (PF) and astragaloside IV (AS‐IV) have protective effects on cerebral ischemia. We aimed to test the effects of combined use of PF and AS‐IV on ischemic brain edema and investigate whether the effects were… read more here.

Keywords: brain edema; edema; cx43; ischemic brain ... See more keywords
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The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity

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recommendations! Published in 2017 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-017-2722-7

Abstract: Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled.… read more here.

Keywords: binding domain; hemichannel activity; sh3 binding; cx43 ... See more keywords
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Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

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recommendations! Published in 2017 at "Basic Research in Cardiology"

DOI: 10.1007/s00395-017-0618-1

Abstract: Mitochondrial connexin 43 (Cx43) plays a key role in cardiac cytoprotection caused by repeated exposure to short periods of non-lethal ischemia/reperfusion, a condition known as ischemic preconditioning. Cx43 also forms calcium (Ca2+)-permeable hemichannels that may… read more here.

Keywords: mitochondrial cx43; cell death; entry; cx43 ... See more keywords
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Establishment and functional characterization of a murine primary Sertoli cell line deficient of connexin43

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recommendations! Published in 2020 at "Cell and Tissue Research"

DOI: 10.1007/s00441-020-03203-y

Abstract: The Sertoli cell (SC) specific connexin43 (Cx43) knockout (SCCx43KO) mouse line is ideal to gain insight into the mechanistic gap junction formation in SC and the seminiferous epithelium. A method for developing primary SC cultures… read more here.

Keywords: connexin43; line; sertoli cell; cx43 ... See more keywords
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Expression and functional regulation of gap junction protein connexin 43 in dermal mesenchymal stem cells from psoriasis patients.

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recommendations! Published in 2020 at "Acta histochemica"

DOI: 10.1016/j.acthis.2020.151550

Abstract: BACKGROUND Psoriasis is a chronic recurrent inflammatory disease. Mesenchymal stem cells (MSCs) can regulate the inflammatory microenvironment, thereby controlling the proliferation, differentiation, and migration of immune cells. Connexin 43(Cx43), a key gap junction protein, has… read more here.

Keywords: psoriasis; dmscs; gap junction; cx43 ... See more keywords
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Direct posttranslational modification of astrocytic connexin 43 proteins by the general anesthetic propofol in the cerebral cortex.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.02.142

Abstract: Propofol is widely used as a general anesthetic and is generally considered to exert its action by regulating neuronal firing via facilitation of GABAA receptors. However, accumulating evidence suggests that propofol also acts on astrocytes,… read more here.

Keywords: gap; propofol; posttranslational modification; general anesthetic ... See more keywords
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Targeting the Cardiac Sodium Channel to Increase Excitability of Stem-Cell Derived Cardiomyocytes

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.138

Abstract: The cardiogenic potential of stem-cell derived cardiomyocytes (iPSC-CM) and their prospective use for cardiac cell therapy crucially depends on their excitability and functional integration in myocardial tissue. Indeed, previous studies from our group have shown… read more here.

Keywords: expression; excitability; ipsc cms; cx43 ... See more keywords
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Novel approach to temozolomide resistance in malignant glioma: connexin43‐directed therapeutics

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recommendations! Published in 2018 at "Current Opinion in Pharmacology"

DOI: 10.1016/j.coph.2018.05.002

Abstract: HighlightsCx43 regulates invasiveness, proliferation, and resistance of malignant glioma.Cx43 provides a permissive niche for the invasion and channel‐mediated TMZ resistance.Targeting Cx43 with C‐terminal peptidomimetics can sensitize glioblastoma to TMZ.Mechanism of action for peptidomimetics may be… read more here.

Keywords: malignant glioma; resistance malignant; resistance; cx43 ... See more keywords
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Regulation of connexin 43 expression in human gingival fibroblasts

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.08.017

Abstract: Aims: Abundance of connexin 43 (Cx43), a transmembrane protein that forms hemichannels (HCs) and gap junctions (GJs), is dynamically regulated in human gingival fibroblasts (GFBLs) during wound healing. This may be important for fast and… read more here.

Keywords: bgr; abundance; gingival; cx43 ... See more keywords
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Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure.

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recommendations! Published in 2021 at "Journal of molecular and cellular cardiology"

DOI: 10.1016/j.yjmcc.2021.05.012

Abstract: BACKGROUND Both gap junctional remodeling and interstitial fibrosis have been linked to impaired electrical conduction velocity (CV) and fatal ventricular arrhythmias in nonischemic heart failure (HF). However, the arrhythmogenic role of the ventricular gap junctional… read more here.

Keywords: arrhythmogenic canine; canine; cx43; canine model ... See more keywords