Cx43 hemichannels contribute to astrocyte-mediated toxicity in sporadic and familial ALS
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DOI: 10.1073/pnas.2107391119
Abstract: Significance Our results demonstrate that connexin 43 hemichannels are the conduits for amyotrophic lateral sclerosis (ALS) astrocyte-mediated motor neuron toxicity and disease spread, acting as a common mechanism that can target both familial ALS and… read more here.
Keywords: familial als; contribute astrocyte; astrocyte mediated; cx43 hemichannels ... See more keywords
Effects of Drugs Formerly Proposed for COVID-19 Treatment on Connexin43 Hemichannels
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DOI: 10.3390/ijms23095018
Abstract: Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels release adenosine triphosphate (ATP), which triggers inflammation. Over the past two years, azithromycin, chloroquine,… read more here.
Keywords: cx43 hemichannels; drugs formerly; covid; connexin43 ... See more keywords