Brain Vacuolation Resulting From Administration of the Type II Ampakine CX717 Is An Artifact Related to Molecular Structure and Chemical Reaction With Tissue Fixative Agents
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DOI: 10.1093/toxsci/kfx277
Abstract: Ampakines are small molecule positive allosteric modulators of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). One class II ("low impact") ampakine, CX717, has been implicated to have a neurotoxic effect based on findings in nonclinical, long-term toxicity studies.… read more here.
Keywords: ampakine cx717; tissue; vacuolation; cx717 ... See more keywords
Low dose ampakine CX717 increases ventilation in a rat model of Pompe Disease
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DOI: 10.1152/physiol.2023.38.s1.5732994
Abstract: Pompe disease (PD) is an autosomal recessive metabolic disorder caused by mutations in the enzyme acid-α-glucosidase (GAA) gene. Loss of GAA function causes pathologic accumulation of cellular glycogen. Both early- and late-onset PD are characterized… read more here.
Keywords: ventilation; physiology; model; cx717 ... See more keywords