PGF2α facilitates pathological retinal angiogenesis by modulating endothelial FOS‐driven ELR + CXC chemokine expression
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216373
Abstract: The pathological retinal angiogenesis often causes blindness. Current anti‐angiogenic therapy for proliferative retinopathy targets the vascular endothelial growth factor (VEGF), but many patients do not radically benefit from this therapy. Herein, we report that circulating… read more here.
Keywords: cxc; pgf2; chemokine expression; ptgfr ... See more keywords
Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01970
Abstract: The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine receptor 3 (CXCR3). With a prototype function of directing temporal and spatial migration… read more here.
Keywords: cxcr3; non redundant; cxc chemokine; chemokine receptor ... See more keywords
The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02159
Abstract: Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells.… read more here.
Keywords: tumor microenvironment; cxc chemokine; immune cells; role cxc ... See more keywords
Insights on CXC chemokine receptor 2 in breast cancer: An emerging target for oncotherapy
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DOI: 10.3892/ol.2019.10957
Abstract: Breast cancer is the most common malignant neoplasm in women worldwide, and the treatment regimens currently available are far from optimal. Targeted therapy, based on molecular typing of breast cancer, is the most precise form… read more here.
Keywords: cancer; chemokine receptor; cxc chemokine; breast cancer ... See more keywords