Microglial IL‐1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1‐mediated neutrophil recruitment and microvessel occlusion
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24359
Abstract: Acute ischemic stroke (AIS), one of the leading causes of mortality worldwide, is characterized by a rapid inflammatory cascade resulting in exacerbation of ischemic brain injury. Microglia are the first immune responders. However, the role… read more here.
Keywords: cxcl1; neutrophil recruitment; brain; brain injury ... See more keywords
CXCL1 confers a survival advantage in Kaposi's sarcoma‐associated herpesvirus‐infected human endothelial cells through STAT3 phosphorylation
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DOI: 10.1002/jmv.28020
Abstract: Many cytokines produced by Kaposi's sarcoma‐associated herpesvirus (KSHV)‐infected cells have been shown to participate in the pathogenesis of KSHV. Determination of the exact role of cytokines in Kaposi's sarcoma (KS) pathogenesis is limited, however, by… read more here.
Keywords: kshv infected; cxcl1; endothelial cells; kshv ... See more keywords
Interleukin‐8, but Not the Related Chemokine CXCL1, Sustains an Autocrine Circuit Necessary for the Properties and Functions of Thyroid Cancer Stem Cells
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DOI: 10.1002/stem.2492
Abstract: Interleukin‐8 (IL‐8/CXCL8) mediates its biological effects through two receptors, CXCR1 and CXCR2. While CXCR1 recognizes IL‐8 and granulocyte chemotactic protein‐2, CXCR2 binds to multiple chemokines including IL‐8, CXCL1, 2 and 3. Both IL‐8 and CXCL1… read more here.
Keywords: cxcl1; cell; thyroid cancer; stem ... See more keywords
CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.10.043
Abstract: Crosstalk between lymphatic endothelial cells (LECs) and tumor cells in the tumor microenvironment plays a crucial role in tumor metastasis. Our previous study indicated chemokine (C-X-C motif) ligand 1 (CXCL1) from LECs stimulates the metastasis… read more here.
Keywords: cxcl1; gastric cancer; integrin fak; fak akt ... See more keywords
Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.014
Abstract: ABSTRACT Painful peripheral neuropathy is the most dose‐limiting side effect of paclitaxel (PTX), a widely used anti‐cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to… read more here.
Keywords: ptx induced; cxcl1; cxcr2; spinal blockage ... See more keywords
Cultured Human Uveal Melanocytes Express/secrete CXCL1 and CXCL2 Constitutively and Increased by Lipopolysaccharide via Activation of Toll-like Receptor 4
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DOI: 10.1080/02713683.2021.1929326
Abstract: ABSTRACT Purpose: Lipopolysaccharide (LPS) can activate Toll-like receptor 4 (TLR4) and increase the expression of CXCL1 and CXCL2, the potent neutrophils chemoattractants, in various cell types. These effects have not been previously reported in the… read more here.
Keywords: cxcl1; lps induced; expression; cxcl1 cxcl2 ... See more keywords
Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway
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DOI: 10.1080/13880209.2023.2198560
Abstract: Abstract Context Daphnetin is a natural product with anti-inflammatory, antioxidant, and neuroprotective properties. Reports have found that it has a strong analgesic effect; however, its analgesic mechanism is unknown. Objective We explored the effect and… read more here.
Keywords: cxcl1; cxcr2; daphnetin alleviates; neuropathic pain ... See more keywords
Inflammation in Murine Aneurysm Healing: The Role of CXCL1
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DOI: 10.1093/neuros/nyz310_109
Abstract: Cerebral aneurysm rupture results in subarachnoid hemorrhage which has a mortality of up to 40%. Current prophylactic treatment options include surgical clipping, flow diversion, and endovascular coiling. A significant drawback of coiling is that up… read more here.
Keywords: cxcl1 neutralizing; coated coils; murine aneurysm; cxcl1 ... See more keywords
E-015 Inflammation in murine aneurysm healing: the role of CXCL1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of NeuroInterventional Surgery"
DOI: 10.1136/neurintsurg-2019-snis.90
Abstract: Introduction Cerebral aneurysms affect up to 5% of the U.S. population and can have devastating consequences. Rupture of cerebral aneurysms results in subarachnoid hemorrhage which has a mortality of up to 40%. Current prophylactic treatment… read more here.
Keywords: coated coils; none; murine aneurysm; cxcl1 ... See more keywords
CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma
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DOI: 10.1371/journal.pone.0188847
Abstract: Cancer-associated fibroblasts (CAFs) have emerged as one of the main factors related to cancer progression, however, the conversion mechanism of normal fibroblasts (NOFs) to CAFs has not been well elucidated. The aim of this study… read more here.
Keywords: cxcl1; oral squamous; squamous cell; associated fibroblasts ... See more keywords
Transcriptomic Profiling reveals Chemokine CXCL1 as a mediator for Neutrophil Recruitment associated with Blood-Retinal Barrier Alteration in Diabetic Retinopathy.
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DOI: 10.2337/db22-0619
Abstract: Inflammation plays an important role in the pathogenesis of diabetic retinopathy (DR). To precisely define the inflammatory mediators, we examined the transcriptomic profile of human retinal endothelial cells exposed to advanced glycation end products which… read more here.
Keywords: blood retinal; cxcl1; retinal barrier; neutrophil recruitment ... See more keywords