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   Articles with "cxcl1" as a keyword



Microglial IL‐1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1‐mediated neutrophil recruitment and microvessel occlusion

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recommendations! Published in 2023 at "Glia"

DOI: 10.1002/glia.24359

Abstract: Acute ischemic stroke (AIS), one of the leading causes of mortality worldwide, is characterized by a rapid inflammatory cascade resulting in exacerbation of ischemic brain injury. Microglia are the first immune responders. However, the role… read more here.

Keywords: cxcl1; neutrophil recruitment; brain; brain injury ... See more keywords

CXCL1 confers a survival advantage in Kaposi's sarcoma‐associated herpesvirus‐infected human endothelial cells through STAT3 phosphorylation

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recommendations! Published in 2022 at "Journal of Medical Virology"

DOI: 10.1002/jmv.28020

Abstract: Many cytokines produced by Kaposi's sarcoma‐associated herpesvirus (KSHV)‐infected cells have been shown to participate in the pathogenesis of KSHV. Determination of the exact role of cytokines in Kaposi's sarcoma (KS) pathogenesis is limited, however, by… read more here.

Keywords: kshv infected; cxcl1; endothelial cells; kshv ... See more keywords

Interleukin‐8, but Not the Related Chemokine CXCL1, Sustains an Autocrine Circuit Necessary for the Properties and Functions of Thyroid Cancer Stem Cells

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recommendations! Published in 2017 at "STEM CELLS"

DOI: 10.1002/stem.2492

Abstract: Interleukin‐8 (IL‐8/CXCL8) mediates its biological effects through two receptors, CXCR1 and CXCR2. While CXCR1 recognizes IL‐8 and granulocyte chemotactic protein‐2, CXCR2 binds to multiple chemokines including IL‐8, CXCL1, 2 and 3. Both IL‐8 and CXCL1… read more here.

Keywords: cxcl1; cell; thyroid cancer; stem ... See more keywords

CXCL1 from tumor-associated lymphatic endothelial cells drives gastric cancer cell into lymphatic system via activating integrin β1/FAK/AKT signaling.

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recommendations! Published in 2017 at "Cancer letters"

DOI: 10.1016/j.canlet.2016.10.043

Abstract: Crosstalk between lymphatic endothelial cells (LECs) and tumor cells in the tumor microenvironment plays a crucial role in tumor metastasis. Our previous study indicated chemokine (C-X-C motif) ligand 1 (CXCL1) from LECs stimulates the metastasis… read more here.

Keywords: cxcl1; gastric cancer; integrin fak; fak akt ... See more keywords

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice

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recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2019.04.014

Abstract: ABSTRACT Painful peripheral neuropathy is the most dose‐limiting side effect of paclitaxel (PTX), a widely used anti‐cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to… read more here.

Keywords: ptx induced; cxcl1; cxcr2; spinal blockage ... See more keywords

Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60174-w

Abstract: Pulmonary infections are characterized by neutrophil recruitment into the lung driven by chemokine ligands of CXCR2, which is expressed on neutrophils, but also present in non-hematopoietic lung cells, in which its role remains unclear. We… read more here.

Keywords: transcytosis; endothelial cells; epithelial endothelial; cxcr2 ... See more keywords

Emodin Decreases Tumor-Associated Macrophages Accumulation and Suppresses Bladder Cancer Development by Inhibiting CXCL1 Secretion from Cancer-Associated Fibroblasts

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recommendations! Published in 2025 at "Nutrition and Cancer"

DOI: 10.1080/01635581.2025.2480309

Abstract: Abstract Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are the most abundant stromal cells in the bladder cancer (BC) microenvironment (TME). However, the detailed mechanisms underlying TAM-CAF communication and their contributions to BC progression remain… read more here.

Keywords: cancer; tumor associated; tumor; cxcl1 ... See more keywords

Cultured Human Uveal Melanocytes Express/secrete CXCL1 and CXCL2 Constitutively and Increased by Lipopolysaccharide via Activation of Toll-like Receptor 4

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recommendations! Published in 2021 at "Current Eye Research"

DOI: 10.1080/02713683.2021.1929326

Abstract: ABSTRACT Purpose: Lipopolysaccharide (LPS) can activate Toll-like receptor 4 (TLR4) and increase the expression of CXCL1 and CXCL2, the potent neutrophils chemoattractants, in various cell types. These effects have not been previously reported in the… read more here.

Keywords: cxcl1; lps induced; expression; cxcl1 cxcl2 ... See more keywords

Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway

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recommendations! Published in 2023 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2023.2198560

Abstract: Abstract Context Daphnetin is a natural product with anti-inflammatory, antioxidant, and neuroprotective properties. Reports have found that it has a strong analgesic effect; however, its analgesic mechanism is unknown. Objective We explored the effect and… read more here.

Keywords: cxcl1; cxcr2; daphnetin alleviates; neuropathic pain ... See more keywords

Inflammation in Murine Aneurysm Healing: The Role of CXCL1

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recommendations! Published in 2019 at "Neurosurgery"

DOI: 10.1093/neuros/nyz310_109

Abstract: Cerebral aneurysm rupture results in subarachnoid hemorrhage which has a mortality of up to 40%. Current prophylactic treatment options include surgical clipping, flow diversion, and endovascular coiling. A significant drawback of coiling is that up… read more here.

Keywords: cxcl1 neutralizing; coated coils; murine aneurysm; cxcl1 ... See more keywords

E-015 Inflammation in murine aneurysm healing: the role of CXCL1

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recommendations! Published in 2019 at "Journal of NeuroInterventional Surgery"

DOI: 10.1136/neurintsurg-2019-snis.90

Abstract: Introduction Cerebral aneurysms affect up to 5% of the U.S. population and can have devastating consequences. Rupture of cerebral aneurysms results in subarachnoid hemorrhage which has a mortality of up to 40%. Current prophylactic treatment… read more here.

Keywords: coated coils; none; murine aneurysm; cxcl1 ... See more keywords