Islet‐Resident Memory T Cells Orchestrate the Immunopathogenesis of Type 1 Diabetes through the FABP4‐CXCL10 Axis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308461
Abstract: Type 1 diabetes (T1D) is a chronic disease characterized by self‐destruction of insulin‐producing pancreatic β cells by cytotoxic T cell activity. However, the pathogenic mechanism of T cell infiltration remains obscure. Recently, tissue‐resident memory T… read more here.
Keywords: trm cells; type diabetes; resident memory; trm ... See more keywords
Serum level of CXCL10 is associated with inflammatory prognostic biomarkers in patients with diffuse large B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2374
Abstract: Inflammatory biomarkers, such as the neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and Glasgow Prognostic Score (GPS) have been proposed to predict prognosis in diffuse large B‐cell lymphoma (DLBCL). C‐X‐C motif ligand… read more here.
Keywords: level cxcl10; high cxcl10; value; cxcl10 ... See more keywords
Study on the changes and significance of CXCL10 level in serum of isolated polymyalgia rheumatica
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Rheumatology"
DOI: 10.1007/s10067-024-07209-7
Abstract: To investigate the significance of CXC chemokine ligand 10 (CXCL10) in the pathogenesis of isolated polymyalgia rheumatica (PMR). The serum of six PMR patients diagnosed and treated at the First Affiliated Hospital of Wannan Medical… read more here.
Keywords: pmr patients; isolated pmr; serum; group ... See more keywords
Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0764-0
Abstract: CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Although CXCL10 is known to be overexpressed in the salivary glands of individuals… read more here.
Keywords: gland ductal; production; salivary gland; cxcl10 ... See more keywords
CXCL10 conditions alveolar macrophages within the premetastatic niche to promote metastasis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer letters"
DOI: 10.1016/j.canlet.2022.215667
Abstract: Formation of the premetastatic niche is triggered by primary tumors and contributes to cancer metastasis. Evidence indicating the roles of macrophages in metastatic niche formation and organ-specific metastatic tropism has been steadily accumulating. However, the… read more here.
Keywords: cxcl10; metastasis; ccl12 expression; premetastatic niche ... See more keywords
Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.033
Abstract: Melanoma is the deadliest skin cancer due to its high rate of metastasis, frequently to the brain. Brain metastases are incurable; therefore, understanding melanoma brain metastasis is of great clinical importance. We used a mouse… read more here.
Keywords: melanoma; cxcr3; metastasis; cxcl10 ... See more keywords
The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNγ-CXCL10-CXCR3 axis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.159
Abstract: RATIONAL Pressure overload induces adaptive and maladaptive cardiac remodeling processes in the heart. Part of the maladaptive process is the cross-talk between cardiomyocytes and macrophages which is dependent on the function of the Activating Transcription… read more here.
Keywords: cross talk; cxcr3; cardiomyocytes macrophages; cardiac remodeling ... See more keywords
Cerebrospinal fluid CXCL10 is associated with the presence of low level CSF HIV during suppressive antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2021.577493
Abstract: Surrogate markers of HIV central nervous system (CNS) persistence are needed because direct HIV measurements from the CNS require specialized protocols and are not always detectable or quantifiable. We analyzed paired plasma and CSF samples… read more here.
Keywords: csf hiv; hiv; csf; cxcl10 ... See more keywords
IFNgamma-inducible CXCL10/CXCR3 axis alters the sensitivity of HEp-2 cells to ionizing radiation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112382
Abstract: Radiotherapy is a conventional approach for anti-cancer treatment, killing tumor cells through damaging cellular DNA. While increasing studies have demonstrated that tumors generated the tolerance to radiation and tumor immune system was found to be… read more here.
Keywords: cxcr3; hep cells; ifngamma; cxcl10 ... See more keywords
MicroRNA-15a-5p acts as a tumor suppressor in histiocytosis by mediating CXCL10-ERK-LIN28a-let-7 axis
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01472-2
Abstract: Erdheim–Chester disease (ECD) is characterized by excessive production and accumulation of histiocytes within multiple tissues and organs. ECD patients harbor recurrent mutations of genes associated with the RAS/RAF/MEK/ERK signaling pathway, particularly, the BRAFV600E mutation. Following… read more here.
Keywords: mir 15a; ecd patients; tumor suppressor; cxcl10 ... See more keywords
Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2163406
Abstract: Abstract Context Vitiligo is a common skin disease with a complex pathogenesis, and so far, no effective treatment is available. Lycium barbarum L. (Solanaceae) polysaccharide (LBP), the main active ingredient of goji berries, has been… read more here.
Keywords: lycium barbarum; vitiligo mice; cxcl9; lbp ... See more keywords