Inhibition of CXCL12/CXCR4 axis as a potential targeted therapy of advanced gastric carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1085
Abstract: The whole outcome for patients with gastric carcinoma (GC) is very poor because most of them remain metastatic disease during survival even at diagnosis or after surgery. Despite many improvements in multiple strategies of chemotherapy,… read more here.
Keywords: cxcr4 axis; targeted therapy; cxcl12 cxcr4; cxcl12 ... See more keywords
The contributory roles of the CXCL12/CXCR4/CXCR7 axis in normal and malignant hematopoiesis: A possible therapeutic target in hematologic malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174831
Abstract: C-X-C motif chemokine 12 (CXCL12), also known as stromal cell-derived factor-1 (SDF-1), is produced by the bone marrow microenvironment. This chemokine binds and activates its cognate receptors C-X-C chemokine receptor type 4 (CXCR4) and C-X-C… read more here.
Keywords: cxcl12 cxcr7; cxcl12; cxcr4 cxcl12; cxcl12 cxcr4 ... See more keywords
CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117534
Abstract: Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is… read more here.
Keywords: microenvironment; cxcr4 axis; metastasis; cxcl12 cxcr4 ... See more keywords
CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Oncogenesis"
DOI: 10.1038/s41389-022-00380-z
Abstract: Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support metabolic needs of plasma cells (PCs) even transferring mitochondria. In this scenario, heterocellular communication and dysregulation… read more here.
Keywords: mscs; myeloma; microenvironment; cxcr4 axis ... See more keywords
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01981-17
Abstract: ABSTRACT Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV… read more here.
Keywords: hcmv; cxcl12 cxcr4; human cytomegalovirus; cxcr4 signaling ... See more keywords
Abstract 60: An emerging paradigm of Cxcl12 & Cxcr4 involvement in breast cancer metastasis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-60
Abstract: The Cxcl12/Cxcr4 signaling axis has been shown to promote metastasis in multiple mouse models of breast carcinoma, and has been linked to breast cancer cell seeding, homing, survival, and proliferation at future metastatic sites. The… read more here.
Keywords: breast cancer; cxcr4; cxcl12 cxcr4; cancer ... See more keywords
Activation of CXCL12/CXCR4 renders colorectal cancer cells less sensitive to radiotherapy via up-regulating the expression of survivin
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370216675068
Abstract: Colorectal cancer is the most common malignancy of the gastrointestinal tract. Surgical treatment combined with radiotherapy is the main treatment course for colorectal cancer; nevertheless, radio-resistance is commonly encountered during the treatment course and seriously… read more here.
Keywords: cxcl12 cxcr4; colorectal cancer; radiotherapy; cancer cells ... See more keywords
CXCL12/CXCR4 signaling-mediated ERK1/2 activation in spinal cord contributes to the pathogenesis of postsurgical pain in rats
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Pain"
DOI: 10.1177/1744806917718753
Abstract: Background It has been demonstrated that upregulation of CXCL12 and CXCR4 in spinal cord involves in the pathogenesis of neuropathic, inflammatory, and cancer pain. However, whether CXCL12/CXCR4 signaling contributes to postsurgical pain remains unknown. The… read more here.
Keywords: cxcl12 cxcr4; postsurgical pain; pain; spinal cord ... See more keywords
Loss of CXCL12/CXCR4 signalling impacts several aspects of cardiovascular development but does not exacerbate Tbx1 haploinsufficiency
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0207251
Abstract: The CXCL12-CXCR4 pathway has crucial roles in stem cell homing and maintenance, neuronal guidance, cancer progression, inflammation, remote-conditioning, cell migration and development. Recently, work in chick suggested that signalling via CXCR4 in neural crest cells… read more here.
Keywords: cxcl12 cxcr4; tbx1; cxcl12; tbx1 haploinsufficiency ... See more keywords
CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00771
Abstract: Cranial neural crest cells (CNCCs), identified by expression of transcription factor Sox9, migrate to the first branchial arch and undergo proliferation and differentiation to form the cartilage and bone structures of the orofacial region, including… read more here.
Keywords: cxcl12 cxcr4; cxcl12; expression; mice ... See more keywords
CXCL12 and CXCR4 as Novel Biomarkers in Uric Acid-Induced Inflammation and Patients with Gouty Arthritis
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030649
Abstract: The aim of this study was to evaluate the expression of chemokine receptor CXCR4 and its ligand CXCL12 in patients with gout and uric acid-induced inflammation. A total of 40 patients with intercritical gout and… read more here.
Keywords: induced inflammation; cxcr4; cxcl12 cxcr4; uric acid ... See more keywords