The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue
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DOI: 10.1371/journal.pone.0187357
Abstract: Chemokine CXCL12 gradients drive chemotaxis in a CXCR4-dependent mechanism and have been implicated in cancer metastasis. While CXCL12 gradients are typically studied in organized, defined environments, the tumor microenvironment is disorganized. In vivo, CXCL12 gradients… read more here.
Keywords: cxcl12 cxcr7; cxcl12 gradients; cxcl12; composition ... See more keywords