Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115047
Abstract: The abnormal CXCL13/CXCR5 axis is involved in many inflammatory diseases and its selective inhibitor, TAK-799 has exhibited strong anti-inflammatory potency. The sequencing of clinical specimens from interstitial cystitis/bladder pain syndrome (IC/BPS) has shown that CXCL13… read more here.
Keywords: cxcl13 cxcr5; cystitis; cxcr5 axis; cxcr5 ... See more keywords
The healing myocardium mobilises a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab181
Abstract: AIMS Recent studies have revealed that B-cells and antibodies can influence inflammation and remodelling following a myocardial infarction (MI) and culminating in heart failure-but the mechanisms underlying these observations remain elusive. We therefore conducted in… read more here.
Keywords: heart; cxcl13 cxcr5; cxcr5; healing myocardium ... See more keywords
Clinical significance of CXCR5-CXCL13 signaling in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e19517
Abstract: e19517 Background: Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells resulting in monoclonal immunoglobulins in the blood, bone marrow, and urine (1). According to a 2019 American Cancer Society (ACS) report,… read more here.
Keywords: cxcr5; cxcl13; cxcl13 cxcr5; multiple myeloma ... See more keywords
Role of the CXCL13/CXCR5 Axis in Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.850998
Abstract: CXCL13 is a B-cell chemokine produced mainly by mesenchymal lymphoid tissue organizer cells, follicular dendritic cells, and human T follicular helper cells. By binding to its receptor, CXCR5, CXCL13 plays an important role in lymphoid… read more here.
Keywords: role; cxcl13; cxcl13 cxcr5; autoimmune diseases ... See more keywords
Potential Role of CXCL13/CXCR5 Signaling in Immune Checkpoint Inhibitor Treatment in Cancer
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DOI: 10.3390/cancers14020294
Abstract: Simple Summary Immunotherapy is currently the backbone of new drug treatments for many cancer patients. CXC chemokine ligand 13 (CXCL13) is an important factor involved in recruiting immune cells that express CXC chemokine receptor type… read more here.
Keywords: cancer; cxcl13 cxcr5; cxcr5 signaling; cxcl13 ... See more keywords