The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23188
Abstract: The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well as impacting epithelial cell motility, CXCL14 contributes to the establishment… read more here.
Keywords: roles chemokine; chemokine cxcl14; cxcl14 cancer; cancer ... See more keywords
Dysregulation of CXCL14 promotes malignant phenotypes of esophageal squamous carcinoma cells via regulating SRC and EGFR signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.144
Abstract: The present study was to identify abnormal methylation genes implicated in esophageal squamous cell carcinoma (ESCC). Genomic methylation alterations in ESCC tissues were analyzed using laser-microdissection and whole-genome bisulfite sequencing. CXCL14 promoter was frequently hypermethylated… read more here.
Keywords: expression; esophageal squamous; escc; cxcl14 ... See more keywords
The chemokine CXCL14 is negatively associated with obesity and concomitant type-2 diabetes in humans
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Obesity"
DOI: 10.1038/s41366-020-00732-y
Abstract: Chemokine (C-X-C motif) ligand-14 (CXCL14) levels are downregulated in experimental rodent models of obesity. Moreover, CXCL14 reportedly favors insulin sensitization in obese mice. Here we examined, for the first time, the role of CXCL14 in… read more here.
Keywords: concomitant type; type diabetes; expression; obesity ... See more keywords
The roles of Y-box-binding protein (YB)-1 and C-X-C motif chemokine ligand 14 (CXCL14) in the progression of prostate cancer via extracellular-signal-regulated kinase (ERK) signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1993537
Abstract: The cold-shock protein Y-box-binding protein (YB)-1 regulates the expression of various chemokines and their receptors at the transcriptional level. Expression of the orphan chemokine CXCL14 is repressed by EGF induced signaling. The possible links between… read more here.
Keywords: erk; prostate cancer; expression; cancer ... See more keywords
Serum CXCL14 levels are associated with serum C-peptide and fatty liver index in T2DM patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of diabetes investigation"
DOI: 10.1111/jdi.13438
Abstract: AIMS/INTRODUCTION Recent studies have suggested C-X-C motif chemokine ligand 14 (CXCL14), secreted from adipose tissue, to play an important role in the pathogenesis of metabolic syndrome. However, the clinical significance of CXCL14 in humans has… read more here.
Keywords: t2dm; index; fatty liver; serum cxcl14 ... See more keywords
Exosomal CXCL14 Contributes to M2 Macrophage Polarization through NF-κB Signaling in Prostate Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7616696
Abstract: Chemokine (C-X-C motif) ligand 14 (CXCL14) plays a critical role in maintaining homeostasis and inflammation in the local cell environment and regulating cancer progression. However, the role of CXCL14 in prostate cancer (PC) has not… read more here.
Keywords: macrophage polarization; cxcl14; prostate cancer; polarization signaling ... See more keywords
Elevated CXCL14 in Induced Sputum Was Associated with Eosinophilic Inflammation and Airway Obstruction in Patients with Asthma
Sign Up to like & getrecommendations! Published in 2022 at "International Archives of Allergy and Immunology"
DOI: 10.1159/000526367
Abstract: Introduction: CXCL14 involved in inflammatory processes was upregulated in the asthma expression profile datasets in our pilot study. However, the expression of CXCL14 in induced sputum and its potential clinical role in asthma were poorly… read more here.
Keywords: induced sputum; inflammation; cxcl14 induced; expression ... See more keywords
CXCL14 facilitates the growth and metastasis of ovarian carcinoma cells via activation of the Wnt/β-catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-021-00913-x
Abstract: Background There is an urgent need to identify potential targets in anticancer therapy to improve the survival and prognosis of patients with ovarian cancer (OC). Herein, we investigated the functional significance of chemokine (C-X-C motif)… read more here.
Keywords: catenin signaling; signaling pathway; growth; cxcl14 ... See more keywords
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216592
Abstract: Alcoholic liver disease (ALD) accounts for a large fraction of patients with cirrhosis and hepatocellular carcinoma. In the present study we investigated the involvement of Brahma‐related gene 1 (Brg1) in ALD pathogenesis and implication in… read more here.
Keywords: brg1 cxcl14; alcoholic liver; cxcl14 axis; expression ... See more keywords
Plasma CXCL14 as a Candidate Biomarker for the Diagnosis of Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.833866
Abstract: Background Effective biomarkers for early diagnosis of lung cancer are needed. Previous studies have indicated positive associations between abnormal circulating cytokines and the etiology of lung cancer. Methods Blood samples were obtained from 286 patients… read more here.
Keywords: lung cancer; biomarker; cxcl14; diagnosis lung ... See more keywords
Aberrant ROS Mediate Cell Cycle and Motility in Colorectal Cancer Cells Through an Oncogenic CXCL14 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.764015
Abstract: Background: Reactive oxygen species (ROS) act as signal mediators to induce tumorigenesis. Objective: This study aims to explore whether chemokine CXCL14 is involved in the proliferation and migration of ROS-induced colorectal cancer (CRC) cells. Methods:… read more here.
Keywords: colorectal cancer; cell cycle; ros; cell ... See more keywords