Prognostic and pathogenic role of CXC Motif Ligand 16 in sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Microbes and infection"
DOI: 10.1016/j.micinf.2021.104882
Abstract: Chemokine CXC motif ligand 16 (CXCL16) is an important mediator that has been shown to participate in various human diseases. The role of CXCL16 in the immunopathology of sepsis remains unidentified. In this study, we… read more here.
Keywords: motif ligand; sepsis; cxc motif; cxcl16 ... See more keywords
Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38766-6
Abstract: Ovarian cancer (OvCa) is the leading cause of death from gynecological malignancies. Five-year survival rate of OvCa ranges from 30–92%, depending on the spread of disease at diagnosis. Role of chemokines is well appreciated in… read more here.
Keywords: ovca; cxcr6; higher cxcl16; cxcl16 ... See more keywords
ELK3-CXCL16 axis determines natural killer cell cytotoxicity via the chemotactic activity of CXCL16 in triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Oncoimmunology"
DOI: 10.1080/2162402x.2023.2190671
Abstract: ABSTRACT Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer because of its aggressive behavior and the limited therapeutic strategies available. In the last decade, immunotherapy has become a promising treatment to… read more here.
Keywords: elk3; breast cancer; cxcl16; expression ... See more keywords
Functional role of endothelial CXCL16/CXCR6-platelet–leucocyte axis in angiotensin II-associated metabolic disorders
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvy135
Abstract: Aims Angiotensin-II (Ang-II) is the main effector peptide of the renin-angiotensin system (RAS) and promotes leucocyte adhesion to the stimulated endothelium. Because RAS activation and Ang-II signalling are implicated in metabolic syndrome (MS) and abdominal… read more here.
Keywords: cxcr6; cxcl16 cxcr6; cxcl16; functional role ... See more keywords
Hepatic CXCL16 is increased in gallstone accompanied with liver injury
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.12788
Abstract: This study aimed to investigate the relationship between circulating soluble C‐X‐C chemokine ligand 16 (CXCL16) levels and clinical characteristics of gallstone. read more here.
Keywords: cxcl16 increased; gallstone accompanied; cxcl16; accompanied liver ... See more keywords
Abstract 1924: Role of CXCL16 and ADAM10 in ovarian cancer pathogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1924
Abstract: Ovarian cancer is the leading cause of death from gynecological malignancies. The five-year survival rate of ovarian cancer ranges from 30 to 92%, depending on the severity of the disease. Our laboratory has shown the… read more here.
Keywords: cxcr6; cxcl16; pathogenesis; ovarian cancer ... See more keywords
Soluble chemokine (C-X-C motif) ligand 16 (CXCL16) in urine as a novel biomarker candidate to identify high grade and muscle invasive urothelial carcinomas
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20737
Abstract: Information on biomarkers of urothelial carcinomas (UC) for clinical decision-making is limited. Here, we newly identified and verified CXCL16 as a promising novel biomarker in urine for high grade and muscle invasive UC in a… read more here.
Keywords: high grade; grade muscle; cxcl16; muscle invasive ... See more keywords
Elevated expression of CXCL16 correlates with poor prognosis in patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Management and Research"
DOI: 10.2147/cmar.s197354
Abstract: Aims: To examine the expression of CXCL16 in colorectal cancer (CRC) tissue and to clarify the relationships between CXCL16 and clinicopathological features and survival in CRC. Methods: A total of 142 consecutive CRC patients undergoing… read more here.
Keywords: expression; cxcl16; crc; expression cxcl16 ... See more keywords
CXCL16/CXCR6 Axis Drives Microglia/Macrophages Phenotype in Physiological Conditions and Plays a Crucial Role in Glioma
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02750
Abstract: Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis. Anti-inflammatory microglia release soluble factors that might promote brain… read more here.
Keywords: anti inflammatory; cxcr6; glioma; drives microglia ... See more keywords
Metabolic Syndrome in Psoriasis Is Associated With Upregulation of CXCL16 on Monocytes and a Dysbalance in Innate Lymphoid Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.916701
Abstract: Psoriasis is frequently associated with the metabolic syndrome and occurs more often in obese individuals. In order to understand innate immune mechanisms mediating this inflammatory pattern we investigated expression of the chemokine and lipid scavenger… read more here.
Keywords: metabolic syndrome; cxcl16; psoriasis associated; expression ... See more keywords
The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071468
Abstract: Reverse signaling is a signaling mechanism where transmembrane or membrane-bound ligands transduce signals and exert biological effects upon binding of their specific receptors, enabling a bidirectional signaling between ligand and receptor-expressing cells. In this study,… read more here.
Keywords: transmembrane; cxcr6; cxcl16; receptor ... See more keywords