Oligomerization State of CXCL4 Chemokines Regulates G Protein-Coupled Receptor Activation.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00704
Abstract: CXCL4 chemokines have antiangiogenic properties, mediated by different mechanisms, including CXCR3 receptor activation. Chemokines have distinct oligomerization states that are correlated with their biological functions. CXCL4 exists as a stable tetramer under physiological conditions. It… read more here.
Keywords: state; receptor activation; cxcl4 chemokines; oligomerization ... See more keywords
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam8458
Abstract: The production of CXCL4 and IFN-α by plasmacytoid DCs in response to TLR8 signaling contributes to skin fibrosis and systemic sclerosis. Plasmacytoid DCs foster fibrosis As potent producers of type I interferon, plasmacytoid dendritic cells… read more here.
Keywords: tlr8; sclerosis; fibrosis; systemic sclerosis ... See more keywords
CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010653
Abstract: CXCL4 is an important biomarker of systemic sclerosis (SSc), an incurable autoimmune disease characterized by vasculopathy and skin/internal organs fibrosis. CXCL4 contributes to the type I interferon (IFN-I) signature, typical of at least half of… read more here.
Keywords: systemic sclerosis; cxcl4 rna; dendritic cells; cxcl4 ... See more keywords