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   Articles with "cxcl4" as a keyword



Oligomerization State of CXCL4 Chemokines Regulates G Protein-Coupled Receptor Activation.

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recommendations! Published in 2017 at "ACS chemical biology"

DOI: 10.1021/acschembio.7b00704

Abstract: CXCL4 chemokines have antiangiogenic properties, mediated by different mechanisms, including CXCR3 receptor activation. Chemokines have distinct oligomerization states that are correlated with their biological functions. CXCL4 exists as a stable tetramer under physiological conditions. It… read more here.

Keywords: state; receptor activation; cxcl4 chemokines; oligomerization ... See more keywords

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

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recommendations! Published in 2018 at "Science Translational Medicine"

DOI: 10.1126/scitranslmed.aam8458

Abstract: The production of CXCL4 and IFN-α by plasmacytoid DCs in response to TLR8 signaling contributes to skin fibrosis and systemic sclerosis. Plasmacytoid DCs foster fibrosis As potent producers of type I interferon, plasmacytoid dendritic cells… read more here.

Keywords: tlr8; sclerosis; fibrosis; systemic sclerosis ... See more keywords

CXCL4-Induced PBMCs Modulate Vascular Extracellular Matrix via Wnt5a-Dependent Matrix Metalloproteinase-7 and Calcifying Extracellular Vesicle Release.

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recommendations! Published in 2025 at "Arteriosclerosis, thrombosis, and vascular biology"

DOI: 10.1161/atvbaha.124.322067

Abstract: BACKGROUND The role of macrophage heterogeneity has become increasingly well-recognized in the study of vascular inflammatory responses. The CXCL4 (chemokine [C-X-C motif] ligand 4)-induced monocyte/macrophage phenotype has been implicated in atherosclerotic plaque destabilization, a key… read more here.

Keywords: cxcl4 induced; cxcl4; release; mmp7 ... See more keywords

CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24010653

Abstract: CXCL4 is an important biomarker of systemic sclerosis (SSc), an incurable autoimmune disease characterized by vasculopathy and skin/internal organs fibrosis. CXCL4 contributes to the type I interferon (IFN-I) signature, typical of at least half of… read more here.

Keywords: systemic sclerosis; cxcl4 rna; dendritic cells; cxcl4 ... See more keywords

The Role of CXCL4 in Systemic Sclerosis: DAMP, Auto-Antigen and Biomarker

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26062421

Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by specific autoantibodies, vasculopathy and fibrosis of the skin and internal organs. In SSc, chronic activation of the immune system is largely sustained by endogenous inflammatory mediators… read more here.

Keywords: disease; cxcl4; ssc; systemic sclerosis ... See more keywords