L‐selectin expression is regulated by CXCL8‐induced reactive oxygen species produced during human neutrophil rolling
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847710
Abstract: Neutrophils destroy invading microorganisms by phagocytosis by bringing them into contact with bactericidal substances, among which ROS are the most important. However, ROS also function as important physiological regulators of cellular signaling pathways. Here, we… read more here.
Keywords: oxygen; response; cxcl8; human neutrophil ... See more keywords
Truncation of CXCL8 to CXCL8(9‐77) enhances actin polymerization and in vivo migration of neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ab0220-470r
Abstract: CXCL8 is the principal human neutrophil‐attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil‐chemotactic and neutrophil‐activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein‐coupled receptors (GPCRs) CXCR1… read more here.
Keywords: truncation; cxcl8 cxcl8; actin polymerization; nh2 terminal ... See more keywords
Conserved structure and function of chemokine CXCL8 between Chinese tree shrews and humans.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.025
Abstract: Chemokines represent a superfamily of small secretion proteins that functionally mediate immune cell transmigration in normal or inflammatory conditions. Although anatomic and polygenetic evidence suggests that tree shrews are primate-like species, understanding of the structure… read more here.
Keywords: shrews humans; tree shrews; tree shrew; chemokine cxcl8 ... See more keywords
Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.04.002
Abstract: BACKGROUND Scratch injury induces Koebner phenomenon in psoriasis. Smoking is also a risk factor for psoriasis. Keratinocytes can produce various psoriasis-related molecules including TNF, IL1 A, IL1B, IL6, IL12B, IL17C, IL23 A, IL36 A, IL36B, IL36 G, CXCL1, CXCL2,… read more here.
Keywords: scratch injury; ccl20; koebner phenomenon; cxcl8 ... See more keywords
Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2018.09.037
Abstract: Macrophages play an important role in the generation of host immune responses against H. pylori. In this study, we investigated the effect of a functionally uncharacterized H. pylori secreted protein HP1173 on macrophage responses. In… read more here.
Keywords: protein; hp1173; rhp1173; cxcl8 ... See more keywords
Serum CXCL8 Concentration Can Be Used as a Noninvasive Marker of Subclinical Rejection After Pediatric Liver Transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004601
Abstract: BACKGROUND This study aimed to explore whether serum CXCL8 concentration can be used as a noninvasive marker of subclinical rejection (SCR) after pediatric liver transplantation (pLT). METHODS Firstly, RNA sequencing (RNA-seq) was performed on 22… read more here.
Keywords: scr; serum cxcl8; cxcl8; transplantation ... See more keywords
The Crucial Role of CXCL8 and Its Receptors in Colorectal Liver Metastasis
Sign Up to like & getrecommendations! Published in 2019 at "Disease Markers"
DOI: 10.1155/2019/8023460
Abstract: CXCL8 (also known as IL-8) can produce different biological effects by binding to its receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 and its receptors are associated with the development of… read more here.
Keywords: receptors colorectal; role cxcl8; colorectal liver; cxcl8 receptors ... See more keywords
Cxcl8/PKC Signaling in the Endothelial Cell Niche Regulates Long-Term Hematopoietic Stem Cell Fate
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-141609
Abstract: The sinusoidal endothelial cell niche is a component of the hematopoietic microenvironment with an important role in regulating hematopoietic stem cell (HSC) fate. Mechanisms by which the niche control the long-term functional and phylogenetic diversity… read more here.
Keywords: endothelial cell; cxcl8; expression; niche ... See more keywords
PDK1/RSK1-dependent C/EBPβ activation is involved in thrombin-induced expression of orosomucoid 1-like 3 (ORMDL3) and IL-8/CXCL8 in human lung epithelial cells
Sign Up to like & getrecommendations! Published in 2017 at "European Respiratory Journal"
DOI: 10.1183/1393003.congress-2017.pa4685
Abstract: Asthma is a chronic inflammatory disease of the airways characterized by airway inflammation and structural modeling. Thrombin is known a coagulation factor and shows a critical role in lung inflammation. Previous study demonstrated that overexpressed… read more here.
Keywords: rsk1; cxcl8; expression; sirna ... See more keywords
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280590
Abstract: C-C motif chemokine receptor-like 2 (CCRL2) is a non-signaling 7 transmembrane receptor that binds chemotactic ligands to shape leukocyte recruitment to sites of inflammation. However, there is a lack of consensus on the ligands that… read more here.
Keywords: motif chemokine; function; chemokine receptor; cxcl8 ... See more keywords
Discovering Novel Biomarkers Associated with the Pathogenesis of Psoriasis: Evidence from Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s354985
Abstract: Objective This study aimed to investigate key biomarkers and their molecular pathogenesis in psoriasis. Methods Differentially expressed genes (DEGs) of datasets (GSE13355, GSE30999, and GSE106992) obtained from Gene Expression Omnibus (GEO) were identified using Venn… read more here.
Keywords: analysis showed; pathogenesis psoriasis; psoriasis; cxcl8 ... See more keywords