Split-Combine Click-SELEX Reveals Ligands Recognizing the Transplant Rejection Biomarker CXCL9.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00789
Abstract: Renal rejection is a major incidence in patients after kidney transplantation and associated with allograft scarring and function loss, especially in antibody-mediated rejection. Regular clinical monitoring of kidney-transplanted patients is thus necessary, but measuring donor-specific… read more here.
Keywords: combine click; click selex; split combine; cxcl9 ... See more keywords
Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γ production in tumor microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0337-6
Abstract: The Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) is generally considered to be an oncogene owing to its ability in enhancing the malignancy of multiple types of tumor cells; however, its role in… read more here.
Keywords: microenvironment; shp2; production; cxcl9 ... See more keywords
Mechanisms of action of Lycium barbarum polysaccharide in protecting against vitiligo mice through modulation of the STAT3-Hsp70-CXCL9/CXCL10 pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2163406
Abstract: Abstract Context Vitiligo is a common skin disease with a complex pathogenesis, and so far, no effective treatment is available. Lycium barbarum L. (Solanaceae) polysaccharide (LBP), the main active ingredient of goji berries, has been… read more here.
Keywords: lycium barbarum; vitiligo mice; cxcl9; lbp ... See more keywords
Biomarkers in Pediatric Hemophagocytic Lymphohistiocytosis With Central Nervous System Involvement: A Cohort Study
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000002937
Abstract: Background: The aim of this study was to analyze the clinical significance of cerebrospinal fluid (CSF) cytokines in hemophagocytic lymphohistiocytosis associated with central nervous system (CNS-HLH). Methods: CSF cytokine levels, including interferon (IFN)-γ, soluble CD25… read more here.
Keywords: cxcl9; cns group; group; scd25 cxcl9 ... See more keywords
The Prognostic Importance of Bronchoalveolar Lavage Fluid CXCL9 During Minimal Acute Rejection on the Risk of Chronic Lung Allograft Dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14397
Abstract: The clinical significance and treatment strategies for minimal acute rejection (grade A1), the most common form of acute rejection (AR), remain controversial. In this retrospective single‐center cohort study of 441 lung transplant recipients, we formally… read more here.
Keywords: risk; minimal acute; acute rejection; cxcl9 ... See more keywords
Endogenous CXCL9 affects prognosis by regulating tumor‐infiltrating natural killer cells in intrahepatic cholangiocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Science"
DOI: 10.1111/cas.14267
Abstract: CXCL9, an IFN‐γ inducible chemokine, has been reported to play versatile roles in tumor‐host interrelationships. However, little is known about its role in intrahepatic cholangiocarcinoma (iCCA). Here, we aimed to elucidate the prognostic and biological… read more here.
Keywords: tumor; intrahepatic cholangiocarcinoma; cxcl9; tumor infiltrating ... See more keywords
Microwave ablation combined with PD‐L1 blockade synergistically promotes Cxcl9‐mediated antitumor immunity
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Science"
DOI: 10.1111/cas.16182
Abstract: Although microwave ablation (MWA) is an important curative therapy in colorectal cancer liver metastasis, recurrence still occurs clinically. Our previous studies have shown that the expression of programmed cell death 1 ligand 1 (PD‐L1) is… read more here.
Keywords: cxcl9; microwave ablation; mwa; tumor ... See more keywords
a Comprehensive Assessment of Plasma cxcl9 and cxcl10 in Improving Clinical Prediction Models for Kidney Allograft Rejection
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DOI: 10.1111/ctr.70299
Abstract: Chemokine levels may predict kidney graft rejection. This study evaluated whether adding early plasma chemokines C‐X‐C motif ligand 9 (CXCL9) or chemokines C‐X‐C motif ligand 10 (CXCL10) measurements to a standard‐of‐care model improves the prediction… read more here.
Keywords: cxcl9; cxcl9 cxcl10; rejection; cxcl10 ... See more keywords
Abstract 3195: Intratumoral electroporation of plasmid IL-12 and CXCL9 with membrane-bound anti-CD3 elicits robust anti-tumor immunity
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-3195
Abstract: Preclinical and clinical studies have demonstrated that plasmid IL-12 (tavokinogene telseplasmid) delivered intratumorally via electroporation (TAVO) induces local expression of IL-12p70, converting immunologically excluded tumors into inflamed immunogenic lesions, which is fundamental to generating objective… read more here.
Keywords: anti tumor; cxcl9; anti cd3; membrane ... See more keywords
CXCL9/10/11, a regulator of PD-L1 expression in gastric cancer
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DOI: 10.1186/s12885-018-4384-8
Abstract: BackgroundProgrammed death-ligand 1 (PD-L1) is an immunosuppressor that plays an important role in cancer treatments. Although majority of the studies demonstrated that PD-L1 expression was regulated by cellular intrinsic and extrinsic controls, and IFN-γ was… read more here.
Keywords: cxcr3; chemokine signaling; gastric cancer; cxcl9 ... See more keywords
High-dimensional longitudinal immune profiling uncovers a dual role of the CXCL9/CXCR3, CXCL13/CXCR5, and CCL11/CCL3 axis in the coupling of immune-related adverse events to immune checkpoint inhibitor response.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.2512
Abstract: 2512 Background: Additional characterization is required to understand the immune network signatures and immunophenotypes that link immune-related adverse events (irAEs) to immune checkpoint inhibitor (ICI) therapy responses in cancer patients. Methods: A comprehensive immune profiling… read more here.
Keywords: oncology; cxcl9; cxcl13; immune related ... See more keywords