Value of CXCL8–CXCR1/2 axis in neoadjuvant chemotherapy for triple-negative breast cancer patients: a retrospective pilot study
Sign Up to like & getrecommendations! Published in 2020 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-020-05660-z
Abstract: Background In this study we investigate the prediction and prognostic value of CXCL8–CXCR1/2 axis for Triple-negative breast cancer (TNBC) patients underwent neoadjuvant chemotherapy (NAC) following standard radical surgery. Methods A total of 303 TNBC patients… read more here.
Keywords: cxcl8 cxcr1; study; value; breast cancer ... See more keywords
Testing an association between TLR4 and CXCR1 gene polymorphisms with susceptibility to urinary tract infection in type 2 diabetes in north Indian population.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2017.10.060
Abstract: BACKGROUND Genetic variations of Toll like receptor 4 (TLR4) and CXC-chemokine receptor type1 (CXCR1), the key elements of innate immune system and their association with urinary tract infection (UTI) were studied in general population. In… read more here.
Keywords: urinary tract; gene; association; tlr4 ... See more keywords
Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz090
Abstract: Abstract Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells (CA-MSCs) are involved in tumor progression and chemoresistance. In this study, we characterize the mechanisms by which naïve mesenchymal stromal cells (MSCs) can… read more here.
Keywords: mesenchymal stromal; stromal cells; tumor cells; cxcr1 ... See more keywords
Association of Single Nucleotide Polymorphisms in the CXCR1, CXCR2 and CXCL5 with the Behçet's Disease in Denizli Province of Turkey.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and experimental dermatology"
DOI: 10.1111/ced.14766
Abstract: BACKGROUND Behçet's disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 mediate the activation and migration of the neutrophils. OBJECTIVES The aim of our study was to investigate… read more here.
Keywords: cxcr2 cxcl5; cxcr1 cxcr2; disease; cxcl5 ... See more keywords
Abstract B058: Role of IL8-CXCR1/2 axis in glioblastoma cell proliferation, invasion, and vascular mimicry
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b058
Abstract: Background: Glioblastoma multiforme (GBM) is the most fatal neoplasm of the central nervous system. There is an ongoing quest for improving GBM therapy owing to limited success in current treatment modalities. Chemokines are known to… read more here.
Keywords: invasion; cell proliferation; role; cxcr1 ... See more keywords
Abstract CT118: A phase I/II trial of a CXCR1/2 inhibitor in combination with anti-PD-1 for circulating tumor DNA (ctDNA) positive & refractoryRAS-mutated microsatellite stable (MSS) colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-ct118
Abstract: Background: Preclinical CRC models reveal KRAS mutations activate the CXCR2 axis promoting an immunosuppressive tumor microenvironment (TME). This occurs via KRAS repression of interferon regulatory factor 2 (IRF2) resulting in upregulation of CXCL3 chemokines, which… read more here.
Keywords: ctdna positive; ctdna; cxcr1; combination ... See more keywords
cAMP response element-binding protein mediates immune-evasion of KRAS-mutant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Lung Cancer"
DOI: 10.1183/23120541.lsc-2021.84
Abstract: Introduction: cAMP response element-binding protein (CREB) mediates proliferative and inflammatory transcription in neurodegeneration and cancer, but its role in malignant immune-evasion is obscure. Objectives: To discover the mechanisms underlying the oncogenic properties of CREB in… read more here.
Keywords: cxcr1; immune evasion; kras mutant; mutant luad ... See more keywords
CXCR1/2 pathways in paclitaxel-induced neuropathic pain
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15533
Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) is a type of neuropathic pain that represents a frequent and serious consequence of chemotherapy agents. Over the last years, significant progress has been achieved in elucidating the underlying pathogenesis of… read more here.
Keywords: paclitaxel induced; reparixin; neuropathic pain; cxcr1 ... See more keywords
Loss of CXC-Chemokine Receptor 1 Expression in Chorioamnionitis Is Associated with Adverse Perinatal Outcomes
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12040882
Abstract: Background: Chorioamnionitis complicates about 1–5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of… read more here.
Keywords: perinatal outcomes; adverse perinatal; cxcr1; loss ... See more keywords