CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.03.001
Abstract: Neutrophils are expanded and abundant in cancer-bearing hosts. Under the influence of CXCR1 and CXCR2 chemokine receptor agonists and other chemotactic factors produced by tumors, neutrophils, and granulocytic myeloid-derived suppressor cells (MDSCs) from cancer patients… read more here.
Keywords: cxcr1 cxcr2; receptor agonists; produced tumors; cytotoxicity ... See more keywords
Association of Single Nucleotide Polymorphisms in the CXCR1, CXCR2 and CXCL5 with the Behçet's Disease in Denizli Province of Turkey.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and experimental dermatology"
DOI: 10.1111/ced.14766
Abstract: BACKGROUND Behçet's disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 mediate the activation and migration of the neutrophils. OBJECTIVES The aim of our study was to investigate… read more here.
Keywords: cxcr2 cxcl5; cxcr1 cxcr2; disease; cxcl5 ... See more keywords
Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine"
DOI: 10.1186/s10020-019-0115-0
Abstract: BackgroundClub Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-inflammatory and immunosuppressive effects, however, its influence on… read more here.
Keywords: oxidative burst; cxcr1 cxcr2; cc16; sera ... See more keywords
Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12812
Abstract: Understanding the relationship between the coexistence of inflammatory and neoplastic processes in ovarian cancer, particularly those involving chemokines and their receptors, may help to elucidate the involvement of the studied parameters in tumor pathogenesis and… read more here.
Keywords: serum peritoneal; ovarian cancer; cxcl8; peritoneal fluid ... See more keywords
Interleukin-8 promotes cell migration via CXCR1 and CXCR2 in liver cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10735
Abstract: Liver cancer (LC), which is one of the most common types of cancer worldwide, is notorious for its high morbidity and mortality rates. Interleukin-8 (IL-8), an important member of the CXC chemokine family that was… read more here.
Keywords: cxcr2; cxcr1 cxcr2; migration; cancer ... See more keywords