A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32412
Abstract: BACKGROUND AND RATIONALE Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigating whether the neonatal liver provides a protumorigenic niche to HB development. METHODS… read more here.
Keywords: cxcl1 cxcr2; niche; neonatal liver; liver ... See more keywords
DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3ab1120-740r
Abstract: Few cytokines/growth modulating proteins are known to be chemoattractants for hematopoietic stem (HSC) and progenitor cells (HPC); stromal cell-derived factor 1α (SDF1α/CXCL12) being the most potent known such protein. DEK, a nuclear DNA-binding chromatin protein… read more here.
Keywords: hematopoietic stem; cxcr2; protein; dek nuclear ... See more keywords
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03183-0
Abstract: Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown… read more here.
Keywords: cxcr2; cxcr2 hepatocytes; kupffer cells; chemokine receptor ... See more keywords
Selective anti-CXCR2 receptor blockade by AZD5069 inhibits CXCL8-mediated pro-tumorigenic activity in human thyroid cancer cells in vitro
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-024-02410-6
Abstract: Thyroid cancer is the most common endocrine malignancy. Current therapies are successful, however some patients progress to therapeutically refractive disease. The immunotherapeutic potential of the CXCL8-chemokine/CXCR2-chemokine-receptor system is currently being explored in numerous human cancers.… read more here.
Keywords: cancer; cxcl8 mediated; cxcr2; thyroid cancer ... See more keywords
Sodium hydrosulfide inhibiting endothelial cells injury and neutrophils activation via IL-8/CXCR2/ROS/NF-κB axis in type 1 diabetes mellitus rat.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.072
Abstract: AIMS Hydrogen sulfide (H2S) prevents endothelial cells injury. However, the complicated mechanism of sodium hydrosulfide (NaHS, a donor that produces H2S) which inhibits the endothelial cells injury which correlated the activation of neutrophil in the… read more here.
Keywords: cells injury; injury; activation; concentration ... See more keywords
Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113812
Abstract: Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid-leucine-arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block CXCLs/CXCR2 axis,… read more here.
Keywords: cxcr2; one derivatives; triazol one; derivatives pyridazinone ... See more keywords
Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.014
Abstract: ABSTRACT Painful peripheral neuropathy is the most dose‐limiting side effect of paclitaxel (PTX), a widely used anti‐cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to… read more here.
Keywords: ptx induced; cxcl1; cxcr2; spinal blockage ... See more keywords
Alveolar epithelial and vascular CXCR2 mediates transcytosis of CXCL1 in inflamed lungs
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60174-w
Abstract: Pulmonary infections are characterized by neutrophil recruitment into the lung driven by chemokine ligands of CXCR2, which is expressed on neutrophils, but also present in non-hematopoietic lung cells, in which its role remains unclear. We… read more here.
Keywords: transcytosis; endothelial cells; epithelial endothelial; cxcr2 ... See more keywords
Bicyclo[2.2.1]heptane containing N,N′-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra01806e
Abstract: CXCR1 and CXCR2 are CXC chemokine receptors (CXCRs), corresponding to cytokines of the CXC chemokine family. CXCR2 was found to be 77% homologous to CXCR1. Antagonism of the chemokine receptor CXCR2 has been proposed as… read more here.
Keywords: cxcr2 selective; cxcr2; heptane containing; containing diarylsquaramide ... See more keywords
Targeting ESE3/EHF with Nifurtimox inhibits CXCR2+ neutrophil infiltration and overcomes pancreatic cancer resistance to chemotherapy and immunotherapy.
Sign Up to like & getrecommendations! Published in 2024 at "Gastroenterology"
DOI: 10.1053/j.gastro.2024.02.046
Abstract: BACKGROUND & AIMS Since pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment. METHODS This study analyzed genomic SNP sequencing, single-cell RNA… read more here.
Keywords: chemotherapy immunotherapy; resistance; cxcr2; ehf ... See more keywords
Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2023.2198560
Abstract: Abstract Context Daphnetin is a natural product with anti-inflammatory, antioxidant, and neuroprotective properties. Reports have found that it has a strong analgesic effect; however, its analgesic mechanism is unknown. Objective We explored the effect and… read more here.
Keywords: cxcl1; cxcr2; daphnetin alleviates; neuropathic pain ... See more keywords