LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "cxcr2" as a keyword



Photo by dipaccicoffeeco from unsplash

A Developmentally Prometastatic Niche to Hepatoblastoma in Neonatal Liver mediated by the Cxcl1/Cxcr2 Axis.

Sign Up to like & get
recommendations! Published in 2022 at "Hepatology"

DOI: 10.1002/hep.32412

Abstract: BACKGROUND AND RATIONALE Hepatoblastoma (HB) is the most common pediatric liver cancer. Its predominant occurrence in very young children led us to investigating whether the neonatal liver provides a protumorigenic niche to HB development. METHODS… read more here.

Keywords: cxcl1 cxcr2; niche; neonatal liver; liver ... See more keywords
Photo from wikipedia

DEK, a nuclear protein, is chemotactic for hematopoietic stem/progenitor cells acting through CXCR2 and Gαi signaling.

Sign Up to like & get
recommendations! Published in 2022 at "Journal of leukocyte biology"

DOI: 10.1002/jlb.3ab1120-740r

Abstract: Few cytokines/growth modulating proteins are known to be chemoattractants for hematopoietic stem (HSC) and progenitor cells (HPC); stromal cell-derived factor 1α (SDF1α/CXCL12) being the most potent known such protein. DEK, a nuclear DNA-binding chromatin protein… read more here.

Keywords: hematopoietic stem; cxcr2; protein; dek nuclear ... See more keywords

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.

Sign Up to like & get
recommendations! Published in 2021 at "Archives of toxicology"

DOI: 10.1007/s00204-021-03183-0

Abstract: Acetaminophen (APAP) is a widely used analgesic, but also a main cause of acute liver injury in the United States and many western countries. APAP hepatotoxicity is associated with a sterile inflammatory response as shown… read more here.

Keywords: cxcr2; cxcr2 hepatocytes; kupffer cells; chemokine receptor ... See more keywords
Photo from wikipedia

Sodium hydrosulfide inhibiting endothelial cells injury and neutrophils activation via IL-8/CXCR2/ROS/NF-κB axis in type 1 diabetes mellitus rat.

Sign Up to like & get
recommendations! Published in 2022 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2022.03.072

Abstract: AIMS Hydrogen sulfide (H2S) prevents endothelial cells injury. However, the complicated mechanism of sodium hydrosulfide (NaHS, a donor that produces H2S) which inhibits the endothelial cells injury which correlated the activation of neutrophil in the… read more here.

Keywords: cells injury; injury; activation; concentration ... See more keywords
Photo by julienlphoto from unsplash

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists.

Sign Up to like & get
recommendations! Published in 2021 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2021.113812

Abstract: Chemokine receptor 2 (CXCR2) is the receptor of glutamic acid-leucine-arginine sequence-contained chemokines CXCs (ELR+ CXCs). In recent years, CXCR2-target treatment strategy has come a long way in cancer therapy. CXCR2 antagonists could block CXCLs/CXCR2 axis,… read more here.

Keywords: cxcr2; one derivatives; triazol one; derivatives pyridazinone ... See more keywords
Photo by vedranafilipovic from unsplash

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice

Sign Up to like & get
recommendations! Published in 2019 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2019.04.014

Abstract: ABSTRACT Painful peripheral neuropathy is the most dose‐limiting side effect of paclitaxel (PTX), a widely used anti‐cancer drug to treat solid tumours. The understanding of the mechanisms involved in this side effect is crucial to… read more here.

Keywords: ptx induced; cxcl1; cxcr2; spinal blockage ... See more keywords
Photo by ricbro from unsplash

Bicyclo[2.2.1]heptane containing N,N′-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents

Sign Up to like & get
recommendations! Published in 2018 at "RSC Advances"

DOI: 10.1039/c8ra01806e

Abstract: CXCR1 and CXCR2 are CXC chemokine receptors (CXCRs), corresponding to cytokines of the CXC chemokine family. CXCR2 was found to be 77% homologous to CXCR1. Antagonism of the chemokine receptor CXCR2 has been proposed as… read more here.

Keywords: cxcr2 selective; cxcr2; heptane containing; containing diarylsquaramide ... See more keywords

Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway

Sign Up to like & get
recommendations! Published in 2023 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2023.2198560

Abstract: Abstract Context Daphnetin is a natural product with anti-inflammatory, antioxidant, and neuroprotective properties. Reports have found that it has a strong analgesic effect; however, its analgesic mechanism is unknown. Objective We explored the effect and… read more here.

Keywords: cxcl1; cxcr2; daphnetin alleviates; neuropathic pain ... See more keywords
Photo from wikipedia

C-X-C chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer

Sign Up to like & get
recommendations! Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1689471

Abstract: ABSTRACT This study aimed to investigate the correlation of C-X-C chemokine receptor 2 (CXCR2) with clinicopathological characteristics and survival in non-small cell lung cancer (NSCLC) patients and further explore its effect on proliferation, apoptosis, invasion,… read more here.

Keywords: jak2 stat3; cxcr2; pathway; cell ... See more keywords
Photo from wikipedia

CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration

Sign Up to like & get
recommendations! Published in 2018 at "European Heart Journal"

DOI: 10.1093/eurheartj/ehy085

Abstract: Aims Chemokine-mediated monocyte infiltration into the damaged heart represents an initial step in inflammation during cardiac remodelling. Our recent study demonstrates a central role for chemokine receptor CXCR2 in monocyte recruitment and hypertension; however, the… read more here.

Keywords: heart; cxcr2; induced cardiac; infiltration ... See more keywords
Photo by nci from unsplash

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents

Sign Up to like & get
recommendations! Published in 2018 at "Royal Society Open Science"

DOI: 10.1098/rsos.180176

Abstract: Metastatic cancer is considered a fatal progression of cancer worldwide. It has been shown that a key player in this scenario is the CXC chemokine receptor 2 (CXCR2). To identify novel CXCR2 antagonists, a pharmacophore… read more here.

Keywords: cxcr2; novel cxcr2; cancer; anti cancer ... See more keywords