Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles.
Sign Up to like & getrecommendations! Published in 2021 at "Dalton transactions"
DOI: 10.1039/d0dt02626c
Abstract: The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist.… read more here.
Keywords: iron oxide; oxide nanoparticles; cxcr4 chemokine; receptor ... See more keywords
Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.821055
Abstract: Chemokine receptors are key G-protein-coupled receptors (GPCRs) that control cell migration in immune system responses, development of cardiovascular and central nervous systems, and numerous diseases. In particular, the CXCR4 chemokine receptor promotes metastasis, tumor growth… read more here.
Keywords: peptide agonist; binding cxcr4; mechanism; cxcr4 chemokine ... See more keywords