CXCR4 expression is associated with proneural‐to‐mesenchymal transition in glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34329
Abstract: Glioblastoma (GBM) is the most common primary intracranial malignant tumor and consists of three molecular subtypes: proneural (PN), mesenchymal (MES) and classical (CL). Transition between PN to MES subtypes (PMT) is the glioma analog of… read more here.
Keywords: cxcr4 expression; mesenchymal transition; proneural mesenchymal; expression ... See more keywords
Somatostatin and CXCR4 expression patterns in adenocarcinoma and squamous cell carcinoma of the lung relative to small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2722-5
Abstract: PurposeLung cancer is highly prevalent and has an especially poor prognosis. Thus, new diagnostic and therapeutic targets are necessary. Two potential targets are somatostatin receptors (SST), which are overexpressed in well-differentiated neuroendocrine neoplasms, and the… read more here.
Keywords: cxcr4 expression; cell; expression; lung cancer ... See more keywords
Prognostic and predictive value of circulating tumor cells and CXCR4 expression as biomarkers for a CXCR4 peptide antagonist in combination with carboplatin-etoposide in small cell lung cancer: exploratory analysis of a phase II study
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0446-z
Abstract: SummaryBackground Circulating tumor cells (CTCs) and chemokine (C-X-C motif) receptor 4 (CXCR4) expression in CTCs and tumor tissue were evaluated as prognostic or predictive markers of CXCR4 peptide antagonist LY2510924 plus carboplatin-etoposide (CE) versus CE… read more here.
Keywords: cxcr4 expression; prognostic predictive; ctcs; tumor ... See more keywords
CXCR4 expression by mesenchymal stromal cells is lost after use of enzymatic dissociation agents, but preserved by use of non-enzymatic methods
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Hematology"
DOI: 10.1007/s12185-020-03043-0
Abstract: In recent years, multipotent mesenchymal stromal cells (MSCs) have demonstrated tremendous potential for use in regenerative medicine. CXCR4, the receptor for CXCL12, is highly expressed by bone marrow (BM) MSCs and the CXCR4/CXCL12 axis has… read more here.
Keywords: dissociation; cxcr4 expression; enzymatic dissociation; enzymatic methods ... See more keywords
Clinical Molecular Imaging of Pulmonary CXCR4 Expression to Predict Outcome of Pirfenidone Treatment in IPF.
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DOI: 10.1016/j.chest.2020.08.2043
Abstract: BACKGROUND IPF is a progressive disease for which two antifibrotic drugs have recently been approved, however there is an unmet need to predict responses to antifibrotic treatment, such as pirfenidone. Recent data suggested that up-regulated… read more here.
Keywords: pulmonary cxcr4; cxcr4 expression; treatment; pirfenidone ... See more keywords
Clinicopathological and prognostic significance of CXCR4 high expression in renal cell carcinoma: a meta-analysis and literature review.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of surgery"
DOI: 10.1016/j.ijsu.2019.08.021
Abstract: INTRODUCTION Previous results have indicated that CXCR4 is an oncogene in several types of human tumors including renal cell carcinoma (RCC). However, the correlation between CXCR4 expression and clinicopathological characteristics of RCC remains unclear. MATERIALS… read more here.
Keywords: renal cell; cxcr4 expression; analysis; cell carcinoma ... See more keywords
Development and Evaluation of an 18F-Radiolabeled Monocyclam Derivative for Imaging CXCR4 Expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00069
Abstract: In humans, C–X–C chemokine receptor type 4 (CXCR4) is a protein that is encoded by the CXCR4 gene and binds the ligand CXCL12 (also known as SDF-1). The CXCR4–CXCL12 interaction in cancer elicits biological activities… read more here.
Keywords: cxcr4 expression; 18f mcfb; 18f radiolabeled; cxcr4 ... See more keywords
The FLT3-ITD mutation and the expression of its downstream signaling intermediates STAT5 and Pim-1 are positively correlated with CXCR4 expression in patients with acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48687-z
Abstract: Chemokine ligand 12(CXCL12) mediates signaling through chemokine receptor 4(CXCR4), which is essential for the homing and maintenance of Hematopoietic stem cells (HSCs) in the bone marrow. FLT3-ITD mutations enhance cell migration toward CXCL12, providing a… read more here.
Keywords: pim; flt3 itd; cxcr4 expression; expression ... See more keywords
Investigation of spleen CXCR4 expression by [68Ga]Pentixafor PET in a cohort of 145 solid cancer patients
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DOI: 10.1186/s13550-021-00822-6
Abstract: Background The chemokine receptor CXCR4 is frequently overexpressed and associated with adverse prognosis in most hematopoietic malignancies and solid cancers. Recently, CXCR4 molecular imaging using the CXCR4-specific positron emission tomography (PET) tracer Pentixafor ([ 68… read more here.
Keywords: pentixafor uptake; cxcr4 expression; spleen pentixafor; cancer ... See more keywords
High CXCR4 expression in pancreatic ductal adenocarcinoma as characterized by an inflammatory tumor phenotype with potential implications for an immunotherapeutic approach.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.4021
Abstract: 4021 Background: Immunotherapy is considered ineffective in the majority of patients with pancreatic ductal adenocarcinoma (PDAC), a consequence of a highly immunosuppressive tumor microenvironment (TME). However, treatment induced inhibition of CXC chemokine receptor 4 (CXCR4)… read more here.
Keywords: expression; cxcr4; tumor; cxcr4 expression ... See more keywords
CXCR4 expression in tumor associated cells in blood is prognostic for progression and survival in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264763
Abstract: The aggressive nature and metastatic potential of pancreatic cancer (PC) results in poor prognosis and high mortality. A better understanding of the underlying biology of PC and the ability of tumor cells to spread to… read more here.
Keywords: pancreatic cancer; cxcr4 expression; tumor; expression ... See more keywords