Development of a NanoBRET-Based Sensitive Screening Method for CXCR4 Ligands.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00182
Abstract: A critical part of the development of CXCR4 modulators is to have a simple and sensitive assay system to complement the search by screening and evaluating the binding affinity. Herein, a NanoBRET assay system was… read more here.
Keywords: nanobret assay; assay system; cxcr4 ligands; development ... See more keywords
Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031156
Abstract: The chemokine receptor CXCR4 and its ligand CXCL12 regulate leukocyte trafficking, homeostasis and functions and are potential therapeutic targets in many diseases such as HIV-1 infection and cancers. Here, we identified new CXCR4 ligands in… read more here.
Keywords: cxcr4 ligands; bis imidazoline; alkyl chain; new cxcr4 ... See more keywords