Epigenetic Regulation of CXCR4 Signaling in Cancer Pathogenesis and Progression.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2022.03.019
Abstract: Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent years has further established… read more here.
Keywords: cancer; regulation cxcr4; cxcr4 signaling; cxcr4 ... See more keywords
Human Cytomegalovirus UL111A and US27 Gene Products Enhance the CXCL12/CXCR4 Signaling Axis via Distinct Mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01981-17
Abstract: ABSTRACT Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV… read more here.
Keywords: hcmv; cxcl12 cxcr4; human cytomegalovirus; cxcr4 signaling ... See more keywords
Combined Inhibition of CXCR4 Signaling and System xc- Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-142735
Abstract: T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that accounts for 10-15% of pediatric and 25% of adult ALL cases. Prior studies have established that most cases pf T-ALL are addicted to… read more here.
Keywords: system; treatment; activity; cxcr4 signaling ... See more keywords
CXCR4 signaling controls dendritic cell location and activation at steady-state and in inflammation.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020006675
Abstract: Dendritic cells (DCs) encompass several cell subsets that collaborate to initiate and regulate immune responses. Proper DC localization determines their function and requires the tightly controlled action of chemokine receptors. All DC subsets express CXCR4,… read more here.
Keywords: state; biology; activation; cxcr4 signaling ... See more keywords
Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4237126
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Shang-Ke-Huang-Shui (SKHS) is a classic traditional Chinese medicine formula originally from the southern China city of Foshan. It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain… read more here.
Keywords: cxcr4 signaling; cxcr4 antagonist; cartilage; cxcr4 ... See more keywords
γδ T Cells May Aggravate Acute Graft-Versus-Host Disease Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.687961
Abstract: Graft-versus-host disease (GVHD) is a pathology in which chemokines and their receptors play essential roles in directing the migration of alloreactive donor T cells into GVHD organs, thereby leading to further target tissue damage. Currently,… read more here.
Keywords: versus host; allogeneic hematopoietic; host disease; cxcr4 signaling ... See more keywords
SDF-1α/CXCR4 signaling promotes capillary tube formation of human retinal vascular endothelial cells by activating ERK1/2 and PI3K pathways in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2022.12821
Abstract: The purpose of this study is to address the effect and mechanism of stromal cell-derived factor-1 (SDF-1)α/chemokine (C-X-C motif) receptor 4 (CXCR4) signaling on capillary tube formation of human retinal vascular endothelial cells (HRECs). The… read more here.
Keywords: cxcr4 signaling; sdf cxcr4; cxcr4; tube formation ... See more keywords