A new approach based on CXCR4-targeted combination liposomes for the treatment of liver fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00242f
Abstract: Liver fibrosis results from excessive extracellular matrix accumulation due to injury and leads to cirrhosis, cancer, and death. Herein, we propose a chemokine receptor 4 (CXCR4)-targeted combination (CTC) liposomal therapy to treat carbon tetrachloride (CCl4)-induced… read more here.
Keywords: cxcr4 targeted; liver fibrosis; ctc lipo; ctc ... See more keywords
CXCR4-Targeted PET Imaging in Hematologic Malignancies
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Nuclear Medicine"
DOI: 10.1097/rlu.0000000000005426
Abstract: Purpose The aims of this study were to perform a comprehensive review and meta-analyses and to report pooled diagnostic results on CXCR4-targeted PET, particularly considering detection, visualization, and prognostication. Patients and Methods This study followed… read more here.
Keywords: hematologic malignancies; cxcr4 targeted; cxcr4 pet; pet ... See more keywords
AI-guided design of a CXCR4-targeted core-shell nanocarrier for co-delivery of berberine/paclitaxel in cancer therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of nanobiotechnology"
DOI: 10.1186/s12951-025-03850-9
Abstract: An integrated three-step artificial-intelligence (AI) workflow was developed to accelerate the design of a CXCR4-targeted, dual-drug nanocarrier for colorectal cancer therapy. The workflow combined AI-based drug synergy prediction, peptide ligand discovery, and formulation optimization to… read more here.
Keywords: cancer; shell; core; therapy ... See more keywords
CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1683585
Abstract: Metastasis remains the prime cause of poor prognosis in lung cancer, a leading cause of cancer-related mortality worldwide. Because CXCR4/CXCL12 constitutes a powerful therapeutic target to counter tumor progression, immune evasion, and therapy resistance, it… read more here.
Keywords: cancer; lung cancer; cxcr4; tumor ... See more keywords
Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10071680
Abstract: Advanced endometrial cancer (EC) lacks therapy, thus, there is a need for novel treatment targets. CXCR4 overexpression is associated with a poor prognosis in several cancers, whereas its inhibition prevents metastases. We assessed CXCR4 expression… read more here.
Keywords: metastasis; endometrial cancer; cxcr4 targeted; therapy ... See more keywords
Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers15010085
Abstract: Simple Summary The fact that most endometrial cancer (EC) patients overexpress the CXCR4 receptor in tumor tissue, especially at incurable advanced stages, opens an avenue for developing novel therapies targeting CXCR4+ EC cells to add… read more here.
Keywords: t22 ditox; endometrial cancer; cxcr4 targeted; cxcr4 ... See more keywords
Combination of PET and CXCR4-Targeted Peptide Molecule Agents for Noninvasive Tumor Monitoring
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer"
DOI: 10.7150/jca.31087
Abstract: Precision medicine is emphasizing not only at individual but also at disease molecule level in modern medicine. Therefore, target-specific molecular agents are crucial for precise diagnosis and treatment. We developed a peptide agent that binds… read more here.
Keywords: medicine; molecule; cxcr4 targeted; combination pet ... See more keywords