Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies
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DOI: 10.1016/j.chembiol.2020.06.006
Abstract: Summary Camelid single-domain antibody fragments (nanobodies) offer the specificity of an antibody in a single 15-kDa immunoglobulin domain. Their small size allows for easy genetic manipulation of the nanobody sequence to incorporate protein tags, facilitating… read more here.
Keywords: monitoring allosteric; hibit; allosteric interactions; interactions cxcr4 ... See more keywords
Pace of Coreceptor Tropism Switch in HIV-1-Infected Individuals after Recent Infection
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DOI: 10.1128/jvi.00793-17
Abstract: ABSTRACT HIV-1 entry into target cells influences several aspects of HIV-1 pathogenesis, including viral tropism, HIV-1 transmission and disease progression, and response to entry inhibitors. The evolution from CCR5- to CXCR4-using strains in a given… read more here.
Keywords: tropism switch; coreceptor; hiv infected; cxcr4 using ... See more keywords