Activated microglia promote invasion and barrier dysfunction of brain endothelial cells via regulating the CXCL13/CXCR5 axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11832
Abstract: The blood brain barrier (BBB) is a protective border that prevents noxious substances from gaining access to the central nervous system (CNS). CXCL13 is a chemokine from the CXC chemokine family, which has been shown… read more here.
Keywords: barrier dysfunction; invasion barrier; cxcr5; bend cells ... See more keywords
PD-1 Expressing CD8+CXCR5+ Follicular T Cells Constitute Effector Rather Than Exhaustive Phenotype in Patients with Chronic Hepatitis B.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32210
Abstract: Classical CD8 T cells are implicated for protective and pathogenic roles in chronic hepatitis B(CHB) infection. Recently, a new subset of CD8 T cells expressing CXCR5 and exhibiting features of TFH cells has been identified… read more here.
Keywords: hbsag hbv; cxcr5; cxcr5 cells; chronic hepatitis ... See more keywords
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115047
Abstract: The abnormal CXCL13/CXCR5 axis is involved in many inflammatory diseases and its selective inhibitor, TAK-799 has exhibited strong anti-inflammatory potency. The sequencing of clinical specimens from interstitial cystitis/bladder pain syndrome (IC/BPS) has shown that CXCL13… read more here.
Keywords: cxcl13 cxcr5; cystitis; cxcr5 axis; cxcr5 ... See more keywords
Responses to Quadrivalent Influenza Vaccine Reveal Distinct Circulating CD4+CXCR5+ T Cell Subsets in Men Living with HIV
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51961-9
Abstract: T cell help for B cells may be perturbed in people living with HIV (PLWH), even when HIV is suppressed, as evidenced by reports of suboptimal responses to influenza vaccination. We investigated cTFH responses to… read more here.
Keywords: influenza vaccine; cxcr5; living hiv; cell ... See more keywords
Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2105822118
Abstract: Significance Our study provides detailed functional and spatial characteristics of immune cells in the LR-CHL microenvironment at single-cell resolution. We describe detailed T cell subset definitions and importantly identified a unique CD4+PD-1+CXCL13+CXCR5− TFH-like subset that… read more here.
Keywords: single cell; cxcr5; chl; biology ... See more keywords
Altered Expression of CXCL13 and Its Chemokine Receptor CXCR5 on B Lymphocytes during Active Graves’ Orbitopathy
Sign Up to like & getrecommendations! Published in 2020 at "Current Eye Research"
DOI: 10.1080/02713683.2020.1786132
Abstract: ABSTRACT Purpose To characterize the phenotypic abnormalities of peripheral B cells in patients with Graves’ orbitopathy (GO) and explore the role of chemokine CXC ligand 13 and its receptor type 5 (CXCL13/CXCR5) in relation to… read more here.
Keywords: cxcr5; graves orbitopathy; expression; receptor ... See more keywords
The healing myocardium mobilises a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab181
Abstract: AIMS Recent studies have revealed that B-cells and antibodies can influence inflammation and remodelling following a myocardial infarction (MI) and culminating in heart failure-but the mechanisms underlying these observations remain elusive. We therefore conducted in… read more here.
Keywords: heart; cxcl13 cxcr5; cxcr5; healing myocardium ... See more keywords
The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "International Immunology"
DOI: 10.1093/intimm/dxac042
Abstract: Abstract Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered according to the course of the disease. However, it is unclear which ICPs… read more here.
Keywords: cell; clinical phenotypes; proliferative activity; systemic lupus ... See more keywords
CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.02507-16
Abstract: ABSTRACT Follicular helper CD4 T cells, TFH, residing in B-cell follicles within secondary lymphoid tissues, are readily infected by AIDS viruses and are a major source of persistent virus despite relative control of viral replication.… read more here.
Keywords: cxcr5; cd8 cells; cell follicles; cell ... See more keywords
Clinical significance of CXCR5-CXCL13 signaling in multiple myeloma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e19517
Abstract: e19517 Background: Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells resulting in monoclonal immunoglobulins in the blood, bone marrow, and urine (1). According to a 2019 American Cancer Society (ACS) report,… read more here.
Keywords: cxcr5; cxcl13; cxcl13 cxcr5; multiple myeloma ... See more keywords
CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2019.00471
Abstract: It is well-established that the chemokine C-X-C motif ligand 13 (CXCL13) and its receptor, the G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory, infectious and immune responses. Originally identified as a B-cell chemoattractant,… read more here.
Keywords: cxcr5; cxcl13 receptor; cancer; cxcl13 ... See more keywords