Structural basis for the recognition of non-methylated DNA by the CXXC domain.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.025
Abstract: CXXC domain-containing proteins are often involved in different biological processes, such as cell proliferation and development, apoptosis, DNA repair, signaling transduction and tumourigenesis, by regulating transcription. 12 CXXC domain-containing proteins have been identified in human,… read more here.
Keywords: domain containing; containing proteins; cxxc domain; biology ... See more keywords
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1101/2022.01.03.474770
Abstract: Wiedemann-Steiner syndrome (WSS) is a neurodevelopmental disorder caused by de novo variants in KMT2A, which encodes a multi-domain histone methyltransferase. To gain insight into the currently unknown pathogenesis of WSS, we examined the spatial distribution… read more here.
Keywords: cxxc domain; steiner syndrome; wiedemann steiner; domain ... See more keywords