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   Articles with "cxxc5" as a keyword



CXXC5 suppresses hepatocellular carcinoma by promoting TGF-&bgr;-induced cell cycle arrest and apoptosis

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recommendations! Published in 2018 at "Journal of Molecular Cell Biology"

DOI: 10.1093/jmcb/mjx042

Abstract: Evading TGF-β-mediated growth inhibition is often associated with tumorigenesis in liver, including hepatocellular carcinoma (HCC). To better understand the functions and the underlying molecular mechanisms of TGF-β in HCC initiation and progression, we carried out… read more here.

Keywords: hepatocellular carcinoma; cxxc5; hcc; promoting tgf ... See more keywords

The KN Motif and Ankyrin Repeat Domains 1/CXXC Finger Protein 5 Axis Regulates Epithelial-Mesenchymal Transformation, Metastasis and Apoptosis of Gastric Cancer via Wnt Signaling

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recommendations! Published in 2020 at "OncoTargets and therapy"

DOI: 10.2147/ott.s240991

Abstract: Background Emerging research indicates that CXXC finger protein 5 (CXXC5) is involved in the development of various cancers. Besides, KN motif and ankyrin repeat domains 1 (KANK1) was proved as a tumor suppressor in multiple… read more here.

Keywords: kank1; cxxc5; catenin axin2; apoptosis ... See more keywords
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Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.680344

Abstract: Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major source of myofibroblasts in the fibrotic livers. In the present… read more here.

Keywords: cxxc5; hsc activation; regulation cxxc5; activation ... See more keywords
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Overexpression of CXXC5 is a strong poor prognostic factor in ER+ breast cancer

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recommendations! Published in 2018 at "Oncology Letters"

DOI: 10.3892/ol.2018.8647

Abstract: CXXC5 is a newly identified CXXC-type zinc finger family protein, which is encoded by the CXXC5 gene localised to the 5q31.3 chromosomal region. Previous studies revealed that CXXC5 is associated with various malignant tumours. The… read more here.

Keywords: cxxc5; prognostic factor; breast; breast cancer ... See more keywords