Zn2+-dependent autocatalytic activity of the Bordetella pertussis CyaA-hemolysin.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.113
Abstract: Proteolytic degradation of the ∼100-kDa isolated RTX (Repeat-in-ToXin) subdomain (CyaA-RTX) of the Bordetella pertussis CyaA-hemolysin (CyaA-Hly) was evidently detected upon solely-prolonged incubation. Here, a truncated CyaA-Hly fragment (CyaA-HP/BI) containing hydrophobic and acylation regions connected with… read more here.
Keywords: zn2 dependent; cyaa; cyaa rtx; bordetella pertussis ... See more keywords
Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells
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DOI: 10.1038/s41598-017-14501-x
Abstract: The adenylate cyclase toxin (CyaA) of the whooping cough agent Bordetella pertussis subverts immune functions of host myeloid cells expressing the αMβ2 integrin (CD11b/CD18, CR3 or Mac-1). CyaA delivers into cytosol of cells an extremely… read more here.
Keywords: cyclase toxin; camp signaling; adenylate cyclase; toxin ... See more keywords
Stability, structural and functional properties of a monomeric, calcium–loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis
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DOI: 10.1038/srep42065
Abstract: Bordetella pertussis, the causative agent of whooping cough, secretes an adenylate cyclase toxin, CyaA, which invades eukaryotic cells and alters their physiology by cAMP overproduction. Calcium is an essential cofactor of CyaA, as it is… read more here.
Keywords: cyclase toxin; bordetella pertussis; adenylate cyclase; calcium ... See more keywords
Identification of c-di-GMP/FleQ-Regulated New Target Genes, Including cyaA, Encoding Adenylate Cyclase, in Pseudomonas putida
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DOI: 10.1128/msystems.00295-21
Abstract: c-di-GMP/FleQ promotes the plankton-to-biofilm lifestyle transition at the transcriptional level via FleQ in Pseudomonas species. Identification of new target genes directly regulated by c-di-GMP/FleQ helps to broaden the knowledge of c-di-GMP/FleQ-mediated transcriptional regulation. ABSTRACT The… read more here.
Keywords: gmp; fleq; gmp fleq; cyaa ... See more keywords
An Introduction to the Toxins Special Issue on the Adenylate Cyclase Toxin
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DOI: 10.3390/toxins10100386
Abstract: The adenylate cyclase (CyaA) toxin is produced by Bordetella pertussis, the causative agent of whooping cough. The incidence of pertussis is currently increasing, and represents a global public health concern. Bordetella pertussis, a Gram-negative bacteria,… read more here.
Keywords: adenylate cyclase; toxin; host; special issue ... See more keywords
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro
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DOI: 10.3390/toxins11020111
Abstract: The adenylate cyclase (CyaA) toxin produced in Bordetella pertussis is the causative agent of whooping cough. CyaA exhibits the remarkable capacity to translocate its N-terminal adenyl cyclase domain (ACD) directly across the plasma membrane into… read more here.
Keywords: pla activity; cyaa; activity; adenylate cyclase ... See more keywords
Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hemolysin to Hemolytic Activity and Ion-Channel Opening
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DOI: 10.3390/toxins9030109
Abstract: The Bordetella pertussis CyaA-hemolysin (CyaA-Hly) domain was previously demonstrated to be an important determinant for hemolysis against target erythrocytes and ion-channel formation in planar lipid bilayers (PLBs). Here, net-charge variations in the pore-lining helix of… read more here.
Keywords: pore lining; ion channel; hemolytic activity; cyaa hly ... See more keywords
Molecular Modeling of the Catalytic Domain of CyaA Deepened the Knowledge of Its Functional Dynamics
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DOI: 10.3390/toxins9070199
Abstract: Although CyaA has been studied for over three decades and revealed itself to be a very good prototype for developing various biotechnological applications, only a little is known about its functional dynamics and about the… read more here.
Keywords: modeling catalytic; functional dynamics; catalytic domain; molecular modeling ... See more keywords