Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists.
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DOI: 10.1021/acs.jmedchem.2c01189
Abstract: Transcriptional enhanced associate domains (TEADs) are transcription factors that bind to cotranscriptional activators like the yes-associated protein (YAP) or its paralog transcriptional coactivator with a PDZ-binding motif (TAZ). TEAD·YAP/TAZ target genes are involved in tissue… read more here.
Keywords: small molecule; cyanamide pan; pan tead; tead yap1 ... See more keywords